{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:39:49Z","timestamp":1790098789316,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","award":["HPRU-2012-10023"],"award-info":[{"award-number":["HPRU-2012-10023"]}],"id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Through record linkage, we describe the causes of death among persons with diagnosis of hepatitis C virus (HCV) in England. Persons \u22651\u00a0year with anti\u2010HCV\/HCV\u2010PCR tests reported to PHE sentinel surveillance during 2002\u20102016 were linked to death registrations from the Office for National Statistics during 2008\u20102016. We found that 8.6% of the 204\u00a0265 with evidence of HCV during the study period died. Among them, external causes (accidental poisoning from drugs) and liver disease (end\u2010stage liver disease, liver cancer, hepatitis, alcohol\u2010 and non\u2013alcohol\u2010related) were the leading underlying causes of death (18% and 34.5%, respectively); the latter increased to 49.2% if reported anywhere on the death certificate. Median age of death was lower in persons with evidence of HCV than the general population (53\u00a0years vs 81\u00a0years). A higher proportion of persons with HCV died of external causes, liver disease and HIV compared to the general population (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Potential impact of new HCV treatments was observed as a relative reduction in liver\u2010related deaths in 2016 compared with 2015. Recording of HCV as a contributory cause of death was 28.4% for all underlying causes, but 58.8% among the subgroup who died of liver disease. Data linkage between laboratory diagnosis and deaths data is an important tool for monitoring all\u2010cause mortality among those with HCV and quantifying under\u2010reporting of HCV in death registrations. Changes in mortality trends (causes and prematurity) in people with HCV can help evaluate the impact in the UK of HCV treatment scale\u2010up and other interventions to achieve HCV elimination.<\/jats:p>","DOI":"10.1111\/jvh.13096","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T11:27:15Z","timestamp":1553167635000},"page":"873-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Causes of death among persons diagnosed with hepatitis C infection in the pre\u2010 and post\u2010DAA era in England: A record linkage study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-0146","authenticated-orcid":false,"given":"Ruth","family":"Simmons","sequence":"first","affiliation":[{"name":"Immunisation, Hepatitis, and Blood Safety Department, National Infection Service Public Health England London UK"},{"name":"The National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-2783","authenticated-orcid":false,"given":"Georgina","family":"Ireland","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis, and Blood Safety Department, National Infection Service Public Health England London UK"},{"name":"The National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Ijaz","sequence":"additional","affiliation":[{"name":"The National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London London UK"},{"name":"Blood\u2010borne Virus Unit, Virus Reference Department, National Infection Service Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis, and Blood Safety Department, National Infection Service Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Mandal","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis, and Blood Safety Department, National Infection Service Public Health England London UK"},{"name":"The National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne, Sexually Transmitted Infections","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Public Health England.Liver disease profiles.https:\/\/fingertips.phe.org.uk\/profile\/liver-disease. 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