{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:55:49Z","timestamp":1789415749146,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15fk0210007h0002"],"award-info":[{"award-number":["15fk0210007h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Abstract<\/jats:title>Prediction of hepatocellular carcinoma (HCC<\/jats:styled-content>) development after sustained virological response (SVR<\/jats:styled-content>) is clinically important, and the usefulness of noninvasive markers for prediction HCC<\/jats:styled-content> have been reported. The aim of this study was to compare the prediction accuracy for HCC<\/jats:styled-content> development by noninvasive markers. A total of 346 patients with chronic hepatitis C without history of HCC<\/jats:styled-content> who achieved SVR<\/jats:styled-content> through direct\u2010acting antivirals were included. Magnetic resonance elastography (MRE<\/jats:styled-content>) and serum fibrosis markers were measured 12\u00a0weeks after the end of treatment, and the subsequent HCC<\/jats:styled-content> development was examined. The mean observation period was 26.4\u00a0\u00b1\u00a07.9\u00a0months, and 24 patients developed HCC<\/jats:styled-content>. Area under the receiver operating characteristic curve of liver stiffness by MRE<\/jats:styled-content>, Wisteria floribunda<\/jats:italic> agglutinin\u2010positive mac\u20102 binding protein and FIB<\/jats:styled-content>\u20104 for predicting HCC<\/jats:styled-content> within 3\u00a0years was 0.743, 0.697 and 0.647, respectively. The 1\/2\/3\u2010year rates of HCC<\/jats:styled-content> development in patients with liver stiffness \u22653.75 KP<\/jats:styled-content>a were 6.6%, 11.9% and 14.5%, whereas they were 1.4%, 2.5% and 2.5% in patients with liver stiffness <3.75 KP<\/jats:styled-content>a (P<\/jats:italic>\u00a0<\u00a00.001). Multivariate analysis revealed that liver stiffness \u22653.75 was an independent predictive factor for HCC<\/jats:styled-content> development (hazard ratio, 3.51; 95% confidence interval, 1.24\u20109.99). In subgroup analysis, there were 132 patients who were <73\u00a0years old and had liver stiffness <3.75 KP<\/jats:styled-content>a, and no HCC<\/jats:styled-content> development was observed in these patients. Diagnostic accuracy for predicting HCC<\/jats:styled-content> development was higher in MRE<\/jats:styled-content> than serum fibrosis markers and measurement of liver stiffness by MRE<\/jats:styled-content> could identify patients with high and low risk of HCC<\/jats:styled-content> development after SVR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.13103","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T04:10:12Z","timestamp":1555042212000},"page":"893-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk assessment of hepatocellular carcinoma development by magnetic resonance elastography in chronic hepatitis C patients who achieved sustained virological responses by direct\u2010acting antivirals"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-6616","authenticated-orcid":false,"given":"Nobuharu","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"},{"name":"First Department of Internal Medicine Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo 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