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Although the majority of cases are asymptomatic during childhood and young adulthood, without an effective treatment, children who acquire HCV via vertical transmission can develop chronic liver disease and other complications including end\u2010stage liver disease and hepatocellular carcinoma in adulthood. Efforts from worldwide health organizations, the pharmaceutical industry, and clinical and research institutions have resulted in very effective interferon\u2010free therapy with direct\u2010acting antiviral agents (DAAs) for HCV\u2010infected children. In this manuscript, we will briefly review the epidemiology of HCV in children, historic treatment, current published data on DAAs in children and conclude with suggestions for management of the child with HCV in the era of DAAs.<\/jats:p>","DOI":"10.1111\/jvh.13113","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T14:08:27Z","timestamp":1555164507000},"page":"1034-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Management of Hepatitis C Infection in children in the era of Direct\u2010acting Antiviral Agents"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-5459","authenticated-orcid":false,"given":"Wikrom","family":"Karnsakul","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"WHO.Global hepatitis report 2017. 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