{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:54:24Z","timestamp":1778961264557,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z151100003915096"],"award-info":[{"award-number":["Z151100003915096"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z161100000516084"],"award-info":[{"award-number":["Z161100000516084"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the efficacy of antepartum administration of three doses of hepatitis B immunoglobulin (HBIG) in interrupting mother\u2010to\u2010child transmission (MTCT) of hepatitis B virus (HBV). In this trial, a total of 728 HBeAg\u2010positive pregnant women with chronic HBV infection who had an HBV DNA level higher than 6log<jats:sub>10<\/jats:sub>\u00a0copies\/mL were enrolled. They were divided into three groups based on individual preference. Subjects in group A and group B received 200\u00a0IU (unit) HBIG and 400\u00a0IU (unit) HBIG intramuscularly once a month at the third, second and first month before delivery, respectively. Subjects in the control group (C) received no special treatment. All the infants received passive\u2010active immunoprophylaxis. The HBsAg\u2010positive rate of all infants at 7\u201012\u00a0months of age was 5.1% (37\/728). Specifically, the HBsAg\u2010positive rate of infants was comparable in all three groups (5.3% vs 5.1% vs 5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.988). No significant difference was found in anti\u2010HBs levels between the infants aged 7\u201012\u00a0months in the three groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.469). HBV DNA levels of the umbilical cord blood in the HBV\u2010infected group were higher than those in the uninfected group (5.2 vs 3.4log<jats:sub>10<\/jats:sub>\u00a0copies\/mL, <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001), and these with family history of HBV infection were also higher (45.9% vs 28.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). To conclude, administration of passive\u2010active immunoprophylaxis to infants contributed to effective prevention of the MTCT of HBV; extra antepartum administration of HBIG during pregnancy could not decrease the rate of MTCT or increase the anti\u2010HBs levels of infants born to HBsAg\u2010positive mothers with HBV DNA higher than 6log<jats:sub>10<\/jats:sub>\u00a0copies\/mL.<\/jats:p>","DOI":"10.1111\/jvh.13123","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T08:15:36Z","timestamp":1557821736000},"page":"1059-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of antepartum administration of hepatitis B immunoglobulin in preventing mother\u2010to\u2010child transmission of hepatitis B virus"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-3054","authenticated-orcid":false,"given":"Mengyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Difficult &amp; Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital Capital Medical University Beijing China"},{"name":"Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaibin","family":"Zou","sequence":"additional","affiliation":[{"name":"Difficult &amp; Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital Capital Medical University Beijing China"},{"name":"Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Difficult &amp; 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