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GT6 prevalence, diversity and real\u2010life response to treatment were studied among 14\u00a0603 HCV mono\u2010infected patients from the French ANRS\u2010CO22\u2010Hepather cohort. NS3, NS5A and NS5B\u2010HCV genes were amplified and sequenced for all GT6\u2010infections identified in the database. Following phylogenic characterization, resistance\u2010associated substitution polymorphisms were identified. GT6\u2010infected patients (n\u00a0=\u00a036; 0.25%) did not differ from patients infected with other genotypes with regard to gender, age or liver fibrosis. GT6e was the most prevalent (27.8%), followed by 6a (22.2%), 6q (11.1%) and 6o (8.3%). Each subtype p and xc were found in two patients (5.6%) and subtypes f\/h\/r and t were each detected in one patient. Four strains (11.1%) clustered with unclassified reference sequences. Concordant genotype determination throughout NS3, NS5A and NS5B\u2010genes is consistent with lack of recombination within this genomic region. All, but three patients were born in Asia, Cambodia (44.4%), Vietnam (38.9%) or Laos (8.3%). GT6a were found in 42.8% of Vietnamese and 6e in 37.5% of Cambodian. GT6q, 6p and 6r were only found in Cambodian patients. Resistance\u2010associated polymorphisms for each DAA classes were identified in baseline sequences. Twenty\u2010seven patients were treated with sofosbuvir\u2010based combinations and 3 with glecaprevir\/pibrentasvir. All treated patients, whether na\u00efve or previously treated, achieved a sustained viral response. In conclusion, GT6\u2010infections are uncommon in France and their genetic diversity likely reflects infection within the country of origin. Despite residue variability at DAA resistance\u2010associated positions, sustained viral response was obtained in all treated patients.<\/jats:p>","DOI":"10.1111\/jvh.13171","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:17:52Z","timestamp":1562311072000},"page":"1276-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic diversity of genotype 6 HCV infections in France: Epidemiology and consequences for treatment strategy"],"prefix":"10.1111","volume":"26","author":[{"given":"Charlotte","family":"Pronier","sequence":"first","affiliation":[{"name":"CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2010 UMR_S 1085 Virology Univ Rennes Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Hepatology, 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