{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:10:36Z","timestamp":1790691036178,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is still some controversy over a potentially increased short\u2010term risk of developing hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) after the initiation of direct\u2010acting antiviral (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>) therapy, even though a decreased long\u2010term risk of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> has been reported following a sustained virological response in patients with chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection. We characterized the time\u2010varying effect of <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s on the risk of the occurrence of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in patients with cirrhosis and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection. We analysed patients with cirrhosis and chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection from the <jats:styled-content style=\"fixed-case\">ANRS CO<\/jats:styled-content>22 <jats:styled-content style=\"fixed-case\">HEPATHER<\/jats:styled-content> cohort study. We excluded patients with active <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> coinfection, liver transplantation or a past history of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. We used a flexible weighted effect cumulative exposure Cox model to characterize the time\u2010varying effect of <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s on the risk of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. A total of 3595 patients, mean age 59.3\u00a0years old, 65% men, were eligible for the study. Median follow\u2010up was 36.8\u00a0months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 24.6\u201047.1). <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s were started during follow\u2010up in 3292 patients. Three hundred and fifty\u2010six <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>s were reported (275 treated, 81 untreated). Overall, a constant decrease in the risk of occurrence of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (vs untreated) was found from the start of treatment. Results were similar in patients without a history of decompensated cirrhosis (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>). Analysis of patients with a past history of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> showed a nonsignificant increase in the occurrence of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> over the first 6\u00a0months, while the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was significantly decreased at 14\u00a0months. These findings support the urgent initiation of <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s in all patients.<\/jats:p>","DOI":"10.1111\/jvh.13186","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T12:59:05Z","timestamp":1565096345000},"page":"1489-1492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The dynamic effect of direct\u2010acting antiviral treatments on the risk of hepatocellular carcinoma in patients with cirrhosis and chronic hepatitis C"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-4228","authenticated-orcid":false,"given":"Clovis","family":"Lusivika\u2010Nzinga","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM Institut Pierre Louis d\u2019\u00e9pid\u00e9miologie et de Sant\u00e9 Publique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie, Assistance Publique \u2010 H\u00f4pitaux de Paris H\u00f4pital Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Dorival","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM Institut Pierre Louis d\u2019\u00e9pid\u00e9miologie et de Sant\u00e9 Publique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Simony","sequence":"additional","affiliation":[{"name":"Unit for Basic and Clinical Research on Viral Hepatitis ANRS (France Recherche Nord&amp;sud Sida\u2010vih H\u00e9patites) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Pol","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie, Assistance Publique \u2010 H\u00f4pitaux de Paris H\u00f4pital Cochin Paris France"},{"name":"INSERM U\u2010123 et USM20, Institut Pasteur Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Carrat","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM Institut Pierre Louis d\u2019\u00e9pid\u00e9miologie et de Sant\u00e9 Publique Paris France"},{"name":"Unit\u00e9 de Sant\u00e9 Publique Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ANRS\/AFEF Hepather study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13659"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32111-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23478"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3701"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29707"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:19:15Z","timestamp":1694243955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jvh.13186"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13186","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"2019-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}