{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:20:16Z","timestamp":1778599216844,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal toxicity of direct\u2010acting antivirals (DAAs) in chronic hepatitis C (CHC) patients has not been well\u2010characterized. The aim of this study was to assess renal safety of DAAs in an Asian CHC patient cohort. Data from CHC patients (n\u00a0=\u00a01536) treated with DAAs were used in this retrospective study. Serial estimated glomerular filtration rate (eGFR) at pretreatment (1\u2010year prior to treatment), baseline, end of treatment (EOT), and 12\u00a0weeks after treatment (SVR<jats:sub>12<\/jats:sub>) was evaluated. While a significant decrease in eGFR from baseline to EOT (84.8\u00a0\u2192\u00a081.8\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) was observed; subsequently, a slight rise at SVR<jats:sub>12<\/jats:sub> (84.3\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>) was also evident. Changes in eGFR after DAA treatment were similar to those seen in PrOD, DCV\/ASV and GZP\/EBV regimens, except in the SOF\u2010based regimen wherein eGFR remained unchanged from EOT to SVR<jats:sub>12<\/jats:sub>, especially in liver transplant recipients. Multivariate analysis revealed that age &gt;65\u00a0years (OR\u00a0=\u00a01.862, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), baseline eGFR\u00a0\u2265\u00a060\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> (OR\u00a0=\u00a02.684, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023), and liver transplant (OR\u00a0=\u00a03.894, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) were independent risk factors for deteriorating renal function. In conclusion, DAA treatment led to a significant decline in eGFR at EOT but was followed by a slight rise at 12\u00a0weeks after treatment. A similar trend was observed with PrOD, DCV\/ASV and GZP\/EBV, but not in SOF\u2010based regimens. As age &gt;65\u00a0years, baseline eGFR\u00a0\u2265\u00a060\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> and liver transplantation are significant risk factors for deterioration in renal function, we strongly advice close monitoring of renal function in these populations.<\/jats:p>","DOI":"10.1111\/jvh.13193","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T19:23:32Z","timestamp":1566415412000},"page":"1404-1412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evolution of renal function under direct\u2010acting antivirals treatment for chronic hepatitis C: A real\u2010world experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-2051","authenticated-orcid":false,"given":"Ming\u2010Chao","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences Chang Gung University College of Medicine Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-3190","authenticated-orcid":false,"given":"Chun\u2010Yen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Linkou Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Nan","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui\u2010Yi","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Nan","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine Keelung Chang 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