{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:16Z","timestamp":1787015776028,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this retrospective study was to observe hepatitis B surface antigen (HBsAg) seroclearance and explore predictors of HBsAg loss in HIV\/HBV\u2010co\u2010infected patients receiving long\u2010term lamivudine or both tenofovir and lamivudine containing therapies. Quantification of HBsAg, hepatitis B e antigen and HBV DNA before and after initiation of HBV\u2010active antiretroviral therapy in a total of 268 HIV\/HBV\u2010co\u2010infected patients started treatment between 2005 and 2017 were performed. Over a median of 65.63\u00a0months of follow\u2010up, 10 (3.7%) were observed HBsAg loss and the quantification of HBsAg in 7 (2.6%) patients were less than 50\u00a0IU\/mL. With the prolongation of antiretroviral therapy duration time, the rates of HBsAg seroclearance tended to increase gradually, rising from 1.8% (3\/163) during 2\u20104\u00a0years treatment to 29.4% (10\/34) after antiretroviral therapy for up to 10\u00a0years. Lower baseline qHBsAg and HBV DNA levels and strong 12\u2010month declines in qHBsAg were significantly associated with HBsAg seroclearance. The event of HBsAg seroclearance is uncommon among Chinese individuals with HIV\/HBV co\u2010infection who have been treated with anti\u2010HBV containing antiretroviral therapy, and lifelong therapy for HBV is needed for HIV\/HBV co\u2010infected patients. Baseline qHBsAg and HBV DNA levels and qHBsAg decline rate were predictors for HBsAg seroclearance.<\/jats:p>","DOI":"10.1111\/jvh.13212","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T02:25:45Z","timestamp":1569896745000},"page":"127-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term observation on hepatitis B surface antigen seroclearance in therapy experienced HIV\/HBV co\u2010infected Chinese"],"prefix":"10.1111","volume":"27","author":[{"given":"Rongrong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-7361","authenticated-orcid":false,"given":"Xien","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengning","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.Progress report 2011: global HIV\/AIDS response.http:\/\/www.who.int\/hiv\/pub\/progress_report2011\/en\/index.html. 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