{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:33:00Z","timestamp":1762867980150,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["NCC\u20101710141"],"award-info":[{"award-number":["NCC\u20101710141"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Republic of Korea has a high prevalence of hepatitis B virus (HBV) infection, and the policies concerning costly antiviral medication have been revised recently. However, in the past 10\u00a0years, no related research on costs has been conducted. The objective of this study was to estimate the economic burden of viral hepatitis B and determine the trend of changes in its costs between 2002 and 2015. Claims data from the National Health Insurance Service were used. To identify viral hepatitis B cases, the ICD\u201010th code B16, B17.0, B18.0 and B18.1 were used based on a primary diagnosis. This study was conducted from a societal perspective regarding both direct and indirect costs. Annual costs were adjusted for inflation by calculations based on the 2015 costs. The number of patients with viral hepatitis B increased from 213\u00a0758 in 2002 to 342\u00a0672 in 2015. The total socio\u2010economic costs increased from 127.1 million USD in 2002 to 459.1 million USD in 2015, mainly due to the increase in pharmaceutical costs, which accounted for the largest proportion of total costs since 2009\u2014220.5 million USD in 2015, which was ~15 times higher than that in 2002. The healthcare costs for viral hepatitis B accounted for 0.13% of the national health expenditure in 2002, increasing to 0.31% in 2015. The economic burden of viral hepatitis B has increased in the Republic of Korea. It is therefore essential to reduce the healthcare costs of HBV infection by establishing an effective management policy.<\/jats:p>","DOI":"10.1111\/jvh.13219","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T11:19:20Z","timestamp":1571743160000},"page":"156-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Costs of viral hepatitis B in the Republic of Korea, 2002\u20102015"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-3740","authenticated-orcid":false,"given":"Dahye","family":"Baik","sequence":"first","affiliation":[{"name":"Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-1162","authenticated-orcid":false,"given":"Byung\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9331-3054","authenticated-orcid":false,"given":"Jin\u2010Kyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-6407","authenticated-orcid":false,"given":"Kyung\u2010Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Ilsan Paik Hospital Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-7104","authenticated-orcid":false,"given":"Moran","family":"Ki","sequence":"additional","affiliation":[{"name":"Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"volume-title":"Global Hepatitis Report 2017","year":"2017","author":"WHO","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","unstructured":"WHO.Guidelines for the Prevention Care and Treatment of Persons with Chronic Hepatitis B Infection: Mar\u201015.Geneva Switzerland:World Health Organization;2015."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200411003-00007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000173419"},{"volume-title":"Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII\u20101)","year":"2016","author":"KCDC","key":"e_1_2_9_6_1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2017.0104"},{"key":"e_1_2_9_8_1","unstructured":"Korean Statistical Information Service (KOSIS) Statistics Korea.Causes of death statistics 2016.http:\/\/kosis.kr\/statisticsList\/statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01#SelectStatsBoxDiv. 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