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We aimed to describe the cascade of HCV care among PWID in Australia, prior to and following unrestricted access to direct\u2010acting antiviral (DAA) treatment. Participants enrolled in an observational cohort study between 2014 and 2018 provided fingerstick whole\u2010blood samples for dried blood spot, Xpert HCV Viral Load and venepuncture samples. Participants underwent transient elastography and clinical assessment by a nurse or general practitioner. Among 839 participants (mean age 43\u00a0years), 66% were male (n\u00a0=\u00a0550), 64% (n\u00a0=\u00a0537) injected drugs in the previous month, and 67% (n\u00a0=\u00a0560) reported currently receiving opioid substitution therapy. Overall, 45% (n\u00a0=\u00a0380) had detectable HCV RNA, of whom 23% (n\u00a0=\u00a086) received HCV treatment within 12\u00a0months of enrolment. HCV treatment uptake increased from 2% in the pre\u2010DAA era to 38% in the DAA era. Significant liver fibrosis (F2\u2010F4) was more common in participants with HCV infection (38%) than those without (19%). Age 50\u00a0years or older (aOR, 2.88; 95% CI, 1.18\u20107.04) and attending a clinical follow\u2010up with nurse (aOR, 3.19; 95% CI, 1.61\u20106.32) or physician (aOR, 11.83; 95% CI, 4.89\u201028.59) were associated with HCV treatment uptake. Recent injection drug use and unstable housing were not associated with HCV treatment uptake. HCV treatment uptake among PWID has increased markedly in the DAA era. Evaluation of innovative and simplified models of care is required to further enhance treatment uptake.<\/jats:p>","DOI":"10.1111\/jvh.13233","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:17:17Z","timestamp":1573172237000},"page":"281-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Hepatitis C virus testing, liver disease assessment and treatment uptake among people who inject drugs pre\u2010 and post\u2010universal access to direct\u2010acting antiviral treatment in Australia: The LiveRLife study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-3845","authenticated-orcid":false,"given":"Sahar","family":"Bajis","sequence":"first","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW 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