{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:41Z","timestamp":1747186781687,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patient\u2010reported outcomes (PROs) are important measures of quality of life. Direct\u2010acting antiviral (DAA) drugs for hepatitis C virus (HCV) improved PROs in clinical trials. We prospectively evaluated the impact of DAA\u2010based HCV cure on PROs and liver\u2010related outcomes in real\u2010world patients at a large urban medical center. The short form (SF)\u201036 and three additional validated instruments were used. F3\u20104 fibrosis was defined as\u00a0&gt;\u00a09.6\u00a0kPa by transient elastography (TE); S2\u20103 steatosis was defined as\u00a0&gt;\u00a0270\u00a0dB\/m by TE\u2010controlled attenuation parameter (CAP). Data were analysed by paired and unpaired t tests. Patients (n\u00a0=\u00a016) who did not achieve a sustained virologic response at 12\u00a0weeks (SVR12) were excluded. The study achieved its primary endpoint and showed a significant 30% improvement in the SF\u201036 vitality score, measured baseline to SVR12: 63 versus 82, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 (n\u00a0=\u00a0111). Scores in 24 of 25 PRO domains improved at SVR12 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Nearly all gains exceeded 5%, indicating their clinical significance. Transaminase values and liver stiffness improved (decreased) significantly, baseline to SVR12 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.005), but steatosis was unchanged (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.58). Patients with baseline F0\u20102 fibrosis and those with F3\u2010F4 fibrosis both improved in 22 domains. Patients with baseline S0\u2010S1 steatosis improved in more domains (23) than patients with S2\u2010S3 steatosis (19). At baseline, patients with F3\u2010F4 fibrosis and patients with S2\u20103 steatosis had worse scores in certain PRO domains than patients with F0\u20102 fibrosis or S0\u2010S1 steatosis, but this difference resolved by SVR12. HCV cure led to meaningful gains in PROs, and these findings may encourage patients to seek treatment.<\/jats:p>","DOI":"10.1111\/jvh.13234","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T13:59:16Z","timestamp":1574171956000},"page":"350-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hepatitis C cure improved patient\u2010reported outcomes in patients with and without liver fibrosis in a prospective study at a large urban medical center"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-1299","authenticated-orcid":false,"given":"Julie C.","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Icahn School of Medicine at Mount Sinai Medical Center New York New 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