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However, VCTE has not been studied in chronic hepatitis D virus (HDV) infection and accuracy remains in question due to the significant hepatic inflammation associated with this infection. Consecutive HBV, HCV and HDV patients who underwent VCTE (2006\u20102019) were evaluated. Diagnosis of cirrhosis was made via liver biopsy or clinical findings. VCTE was compared with other noninvasive serum fibrosis tests using AUROC curves. The performance of VCTE in HBV\/HCV\/HDV was also compared. We evaluated 319 patients (HBV\u2010112; HCV\u2010132; HDV\u201075), 278(87%) patients had histology for evaluation. HDV patients had evidence of higher hepatic inflammation as evidence by aspartate aminotransferase, alanine aminotransferase and histology activity index. Cirrhotic HDV patients had higher mean liver stiffness measurements compared with noncirrhotic patients (29.0 vs 8.3\u00a0kPa, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). VCTE demonstrated excellent diagnostic accuracy for the detection of cirrhosis with an AUROC of 0.90 compared with APRI (0.83), FIB\u20104 (0.88), AAR (0.73) and RPR (0.85). Performance of VCTE in HDV was comparable with HBV (0.93) and HCV (0.94). At the optimized cut\u2010off value of \u226514.0\u00a0kPa for determining cirrhosis in HDV, VCTE had a sensitivity of 0.78, specificity of 0.86, NPV of 0.93 and PPV of 0.64. Hence, VCTE is a useful noninvasive test in HDV for determining cirrhosis despite the presence of significant hepatic inflammation.<\/jats:p>","DOI":"10.1111\/jvh.13235","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T14:00:52Z","timestamp":1574172052000},"page":"428-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Vibration\u2010controlled transient elastography for the detection of cirrhosis in chronic hepatitis D infection"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-240X","authenticated-orcid":false,"given":"Ben L.","family":"Da","sequence":"first","affiliation":[{"name":"Digestive Diseases Branch National Institute of Diabetes &amp; Digestive &amp; Kidney Diseases National Institutes of Health Bethesda MD 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