{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:19:29Z","timestamp":1790191169135,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670533"],"award-info":[{"award-number":["81670533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antiviral therapy has been shown to improve the prognosis of hepatitis B virus (HBV) DNA\u2010positive hepatocellular carcinoma (HCC) after radical treatment, but antiviral treatments require further optimization. This study aimed to evaluate the efficacies of different antiviral strategies with HCC patients after hepatectomy\/ablation. This prospective, randomized, controlled and multi\u2010centre trial enrolled HBV DNA\u2010positive primary HCC patients after hepatectomy\/ablation between January 2007 and January 2009. Patients were divided into four groups: early combination (entecavir plus Peg\u2010interferon [IFN]\u03b1\u20102a co\u2010administration during year 1); late combination (addition of Peg\u2010IFN\u03b1\u20102a for 48\u00a0weeks after 1\u00a0year of entecavir); nucleos(t)ide analogue[NA] monotherapy; and non\u2010antiviral treatment. Primary endpoints included recurrence\u2010free survival and overall survival. A total of 447 patients were enrolled. The 2\u2010year and 8\u2010year recurrence\u2010free survival and 8\u2010year overall survival rates were significantly higher in the early combination group than in the other two antiviral groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). After 48\u2010week treatment, more patients achieved an HBsAg reduction &gt;1500\u00a0IU\/mL and the mean HBsAg level was significantly lower in the early combination group compared with the late combination and NA monotherapy groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Multivariate analysis showed that early combination therapy and a reduction in HBsAg by &gt;1500\u00a0IU\/mL after 48\u00a0weeks of therapy correlated with reduced mortality and disease recurrence. Early introduction of combination antiviral treatment may represent a more effective therapeutic strategy for patients with HBV DNA\u2010positive HCC after hepatectomy\/ablation. A reduction in HBsAg by &gt;1500\u00a0IU\/mL after 48\u2010week treatment is associated with reduced mortality and disease recurrence of HBV DNA\u2010positive HCC patients after hepatectomy\/ablation.<\/jats:p>","DOI":"10.1111\/jvh.13236","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T06:38:37Z","timestamp":1574404717000},"page":"387-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Peg\u2010interferon and nucleos(t)ide analogue combination at inception of antiviral therapy improves both anti\u2010HBV efficacy and long\u2010term survival among HBV DNA\u2010positive hepatocellular carcinoma patients after hepatectomy\/ablation"],"prefix":"10.1111","volume":"27","author":[{"given":"Wenqian","family":"Qi","sequence":"first","affiliation":[{"name":"Digestive Department China\u2010Japan Union Hospital of Jilin University Changchun 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