{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:51:11Z","timestamp":1774029071092,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To achieve elimination of hepatitis C (HCV), a critical group to prioritise for diagnosis and treatment is the prison population, where HCV prevalence is high. A universal offer of blood\u2010borne virus testing (UOBBVT) programme and a new treatment pathway were introduced to seven North East England (NEE) Prisons. Our aim was to assess: (a) the proportion of individuals with active HCV commencing direct\u2010acting antivirals (DAAs); (b) the outcomes following DAA treatment; (3) the reinfection rate following sustained virological response (SVR).<\/jats:p><jats:p>Data were collected prospectively on BBVT uptake, HCV positivity, HCV treatment outcomes and reinfection from March 2016 onwards. 8538 individuals had BBV testing. In total, 612 (7.2%) and 374 (4.4%) were HCV antibody positive and HCV RNA positive, respectively. Ultimately, 266 (71%) individuals commenced DAAs. Overall 111 achieved a documented SVR (42%), 17 (6%) failed treatment, 30 (11%) were still on treatment or had not reached 12\u00a0weeks post\u2010treatment at time of analysis, and 108 (41%) were lost to follow\u2010up. In those with a known outcome (n\u00a0=\u00a0128), 87% achieved SVR. Worryingly, of those who achieved SVR, 21 (19%) were subsequently identified as having been reinfected (median time from SVR to documented reinfection 13 (range 7\u201025)\u00a0months). The reinfection rate was 0.406 cases per person\u2010year follow\u2010up. In conclusion, Implementation of a UOBBVT programme and new treatment pathway resulted in increased diagnosis and treatment of HCV in the NEE prison population. However, the high HCV reinfection rate suggests a need to improve harm reduction approaches.<\/jats:p>","DOI":"10.1111\/jvh.13240","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T09:24:06Z","timestamp":1574328246000},"page":"449-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["High rate of hepatitis C reinfection following antiviral treatment in the North East England Prisons"],"prefix":"10.1111","volume":"27","author":[{"given":"Rajan","family":"Bhandari","sequence":"first","affiliation":[{"name":"Viral Hepatitis Service Newcastle upon Tyne Hospitals NHS Foundation Trust Freeman Hospital Newcastle upon Tyne UK"},{"name":"Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Morey","sequence":"additional","affiliation":[{"name":"Northumbria University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abi","family":"Hamoodi","sequence":"additional","affiliation":[{"name":"Public Health England PHE North East Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Thompson","sequence":"additional","affiliation":[{"name":"G4S Health Services Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee","family":"Jones","sequence":"additional","affiliation":[{"name":"G4S Health Services Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Hewett","sequence":"additional","affiliation":[{"name":"G4S Health Services Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewan","family":"Hunter","sequence":"additional","affiliation":[{"name":"Viral Hepatitis Service Newcastle upon Tyne Hospitals NHS Foundation Trust Freeman Hospital Newcastle upon Tyne UK"},{"name":"Department of Infection and Tropical Medicine Newcastle upon Tyne Hospitals NHS Foundation Trust Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusri","family":"Taha","sequence":"additional","affiliation":[{"name":"Viral Hepatitis Service Newcastle upon Tyne Hospitals NHS Foundation Trust Freeman Hospital Newcastle upon Tyne UK"},{"name":"Department of Infection and Tropical Medicine Newcastle upon Tyne Hospitals NHS Foundation Trust Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-2453","authenticated-orcid":false,"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[{"name":"Viral Hepatitis Service Newcastle upon Tyne Hospitals NHS Foundation Trust Freeman Hospital Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Global health sector strategy on viral hepatitis 2016\u20132021. Glob Hepat Program Dep HIV\/AIDS.2016;56:WHO\/HIV\/2016.06."},{"key":"e_1_2_8_3_1","unstructured":"Public Health England.Hepatitis C in England 2019 report. April 2019;1\u201030.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/732469\/HCV_in-England_2019.pdf"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62474-5"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"e554\u2013e562","article-title":"Hepatitis C in a prison in the North East of England: What is the economic impact of the universal offer of testing and emergent medications?","volume":"38","author":"Darke J","year":"2016","journal-title":"J Public Health"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy210"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.008"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:58:52Z","timestamp":1694073532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,5]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jvh.13240"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13240","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,5]]},"assertion":[{"value":"2019-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}