{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:04:30Z","timestamp":1754111070296,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elbasvir\/grazoprevir with or without ribavirin has excellent efficacy and safety for the treatment of hepatitis C virus (HCV) genotype 1 and 4 patients. The real\u2010world experience has been reported but the detailed analysis of liver and renal adverse effects is lacking. This study evaluated the real\u2010world experience relating to the effectiveness and liver\/renal safety of elbasvir\/grazoprevir in HCV genotype 1 patients with compensated liver disease. In the four medical centres of Chang Gung Medical System, 350 HCV genotype 1 patients with compensated liver disease who were treated with elbasvir\/grazoprevir were enrolled. Clinical characteristics and laboratory data were collected. The effectiveness (sustained virologic response 12\u00a0weeks after end of treatment, SVR12) and safety were assessed. A consecutive series of 350 patients with a mean age of 68.8\u00a0\u00b1\u00a010.0\u00a0years old were enrolled. The majority were treatment\u2010na\u00efve (72.3%), genotype 1b (97.7%) and advanced fibrosis\/cirrhosis (94.3%). Seventy\u2010nine (22.6%) had hepatocellular carcinoma and 23 (6.6%) had coinfection with hepatitis B. The effectiveness of SVR12 was 94.6% (95% CI: 92.2%\u201097.0%) in the full analysis set and 99.1% (95% CI: 98.1%\u2010100.1%) in the per\u2010protocol set. There were two relapses and one nonresponder. Seven (2.0%) patients had adverse events resulting in premature discontinuation of treatment. Five of them were considered drug\u2010related. One was due to autoimmune hepatitis. Contrary to previous reports, around 49% of ALT elevation was observed after 8\u00a0weeks, and in two patients was due to hepatitis B flares. As to the renal function during the course of therapy, a minor deterioration of eGFR was observed in patients with baseline eGFR \u226560\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, but not in those with baseline eGFR &lt;60, &lt;60\u201030 or &lt;30\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>. In this real\u2010world data, elbasvir\/grazoprevir was effective with few liver\/renal adverse effects. One patient developed autoimmune hepatitis.<\/jats:p>","DOI":"10.1111\/jvh.13262","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T12:34:01Z","timestamp":1581338041000},"page":"505-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world experience of elbasvir\/grazoprevir in Taiwan: This study was focused on liver and renal adverse effects"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-4399","authenticated-orcid":false,"given":"Yi\u2010Chung","family":"Hsieh","sequence":"first","affiliation":[{"name":"Division of Hepatogastroenterology Linkou Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Lang","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Keelung Chang Gung Memorial Hospital Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Division of Hepatogastroenterology Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui\u2010Yi","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Chiayi Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan 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