{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:00:27Z","timestamp":1790805627047,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prompt access to confirmatory viral load testing and staging of liver disease are key barriers in uptake of treatment for chronic hepatitis B and C infection. Our objective was to establish the feasibility of a same day \u2018test and treat\u2019 model in two distinct community\u2010based settings in Egypt through use of key point\u2010of\u2010care\u00a0(POC) portable tools for HCV and HBV viral load assessment and staging of liver disease followed by treatment initiation. Community sites were a village in northern Egypt (site 1) and a government office in Cairo (site 2). The following model was adopted: community awareness raising in the week before project initiation; site assessment to ensure optimal placement and calibration of equipment and clinical care set\u2010up; transfer of key portable laboratory instruments to the sites (four cartridge GeneXpert, FibroScan and abdominal ultrasound); screening using rapid diagnostic tests for HCV\u2010Ab and HBsAg, with immediate venous or finger\u2010stick blood sampling for HCV\u2010RNA and HBV\u2010DNA assay, FibroScan staging of liver disease and ultrasound screening for liver cancer. At site 1, 475 individuals were screened over a single day, 125 were positive for HCV\u2010Ab and 4 for HBsAg, 43 of 56 new HCV diagnoses were HCV RNA positive, and 3 of 4 HBsAg\u00a0positive were HBV DNA positive, 40 initiated HCV treatment, and one HBV\u00a0treatment\u00a0. At site 2, 3188 individuals were screened over 3\u00a0days, 157 were positive for HCV\u2010Ab, and 27 for HBsAg; 38 of 76 new HCV diagnoses were HCV RNA positive, and 15 of 18 HBsAg\u00a0positive\u00a0were HBV\u2010DNA positive. Across both sites, 78 patients were counselled and initiated on treatment for HCV and 12 for HBV within 3 and 4\u00a0hours, respectively, of initial positive rapid diagnostic test result. We have shown the feasibility of a same day \u2018test and treat\u2019 model for chronic HCV and HBV infection in two community\u2010based settings in Egypt that achieved high levels of linkage to care and initial treatment.<\/jats:p>","DOI":"10.1111\/jvh.13268","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T17:56:45Z","timestamp":1580407005000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A same day \u2018test and treat\u2019 model for chronic HCV and HBV infection: Results from two community\u2010based pilot studies in Egypt"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-8854","authenticated-orcid":false,"given":"Gamal","family":"Shiha","sequence":"first","affiliation":[{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH) Mansoura Egypt"},{"name":"Hepatology and Gastroenterology Unit Internal Medicine Department Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-9748","authenticated-orcid":false,"given":"Reham","family":"Soliman","sequence":"additional","affiliation":[{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH) Mansoura Egypt"},{"name":"Tropical Medicine Department Faculty of Medicine Port Said University Port Said Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalhamed","family":"Serwah","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Faculty of Medicine Suez Canal University (SCU) Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabiel N. H.","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Egyptian Liver Research Institute and Hospital (ELRIAH) Mansoura Egypt"},{"name":"Department of Biostatistics and Cancer Epidemiology South Egypt Cancer Institute Assiut University Asyut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-0595","authenticated-orcid":false,"given":"Tarik","family":"Asselah","sequence":"additional","affiliation":[{"name":"INSERM UMR1149 Hepatology, Hospital Beaujon Centre de Recherche sur l'Inflammation (CRI) University Paris Diderot Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Easterbrook","sequence":"additional","affiliation":[{"name":"Global Hepatitis Programme Department of HIV, Hepatitis and STIs (HHS) World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021","author":"World Health Organization","year":"2016"},{"key":"e_1_2_8_3_1","volume-title":"Global Hepatitis Report, 2017","author":"World Health Organization","year":"2017"},{"key":"e_1_2_8_4_1","volume-title":"Progress Report on HIV, Viral Hepatitis and Sexually Transmitted Infections 2019. 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