{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:09:11Z","timestamp":1787792951193,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nowadays, intensive immunosuppressive therapy including rituximab is commonly used prior to kidney transplantation (KT), raising concerns over hepatitis B virus (HBV) reactivation among hepatitis B surface antigen (HBsAg)\u2010negative and anti\u2010hepatitis B core (HBc)\u2010positive KT recipients. Recent practice guidelines suggested watchful monitoring or antiviral prophylaxis for the first 6\u201012\u00a0months, the period of maximal immunosuppression. However, the actual risk for HBV reactivation, and whether short\u2010term antiviral therapy in the early period is necessary, remains unclear. A total of 449 HBsAg\u2010negative and anti\u2010HBc\u2010positive KT recipients were analysed for HBV reactivation. During a median follow\u2010up of 6.7 (interquartile range: 4.2\u20109.4) years, HBV reactivation was observed in 9 patients (2.0%). The median time of HBV reactivation from KT was 2.8\u00a0years (range: 1.4\u201011.5\u00a0years), with cumulative incidence rates of 0%, 1% and 2% for 1, 3 and 5\u00a0years, respectively. There were no severe adverse outcomes, including liver transplantation or mortality related to HBV reactivation. The risk of HBV reactivation was not high, even in anti\u2010HBs\u2010negative patients (n\u00a0=\u00a060, 4% at 5\u00a0years), ABO mismatch (n\u00a0=\u00a092, 4% at 5\u00a0years), use of rituximab (n\u00a0=\u00a066, 3% at 5\u00a0years) or plasmapheresis (n\u00a0=\u00a017, 7% at 5\u00a0years), and acute rejection (n\u00a0=\u00a0169, 3% at 5\u00a0years). In conclusion, the HBV reactivation risk was not high and the time of detection was not clustered in the early post\u2010KT period. Our findings favour continued watchful monitoring over antiviral prophylaxis in the early period.<\/jats:p>","DOI":"10.1111\/jvh.13279","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T11:46:20Z","timestamp":1581680780000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hepatitis B reactivation after kidney transplantation in hepatitis B surface antigen\u2010negative, core antibody\u2010positive recipients"],"prefix":"10.1111","volume":"27","author":[{"given":"Jihye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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