{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:48Z","timestamp":1747186788876,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Direct\u2010acting antiviral drugs (DAAs) have recently changed the paradigm of hepatitis C therapy, significantly improving treatment response rates, patient life expectancy and quality of life. In Portugal, sofosbuvir (SOF) and SOF\/ledipasvir (SOF\/LDV) were fully reimbursed by the National Health System since early 2015 and generalized use of interferon\u2010free DAA based regimens became current practice. During 2016, the remaining DAAs were sequentially added and covered by the same health access policy. The Portuguese Study Group of Hepatitis and HIV Co\u2010infection (GEPCOI) collected data from 15 clinical centres in Portugal, pertaining to the HCV treatment experience with DAA regimens. A cohort of 2133 patients was analysed, representing one of the largest DAA treated HCV\/HIV co\u2010infected individuals. The global sustained virologic response (SVR) achieved was 95% in this real\u2010life cohort setting. Linear regression analysis showed significant differences in treatment response rates when using SOF plus ribavirin (RBV) combination in genotype 2 or 3 infected individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.002) and in those with liver cirrhosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.002). These findings corroborate that early treatment is mandatory in HIV\/HCV co\u2010infected patients, as response rates may be negatively influenced by higher fibrosis stages and suboptimal DAA regimens. The current national Portuguese health policy should continue to promote wider treatment access and individualized therapy strategies, aiming at the elimination of HCV infection in this high\u2010risk co\u2010infected population.<\/jats:p>","DOI":"10.1111\/jvh.13281","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T06:31:49Z","timestamp":1582612309000},"page":"715-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic hepatitis C treatment in HIV co\u2010infection in Portugal: Results from a cohort OF 2133 patients presented by GEPCOI (Portuguese Coinfection Study Group)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-9651","authenticated-orcid":false,"given":"Ana Cl\u00e1udia","family":"Miranda","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Infecciologia e Medicina Tropical Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Mendez","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1rio","family":"Serr\u00e3o","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar de S\u00e3o Jo\u00e3o Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vale","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar de Set\u00fabal Set\u00fabal Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Manata","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar Universit\u00e1rio de Lisboa Central Hospital de Curry Cabral Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pinto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar de Gaia\/Espinho Gaia\/Espinho Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Gomes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Infecciologia Hospital Garcia de Orta, EPE Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Valente","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Hospital Fernando da Fonseca Amadora Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1rio","family":"Pazos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Centro Hospitalar Universit\u00e1rio do Algarve, Hospital de Portim\u00e3o Portim\u00e3o Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Pereira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar Universit\u00e1rio do Algarve Hospital de Faro Faro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Martins","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar do Baixo Vouga Aveiro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Germano","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina 1.4 Centro Hospitalar Universit\u00e1rio de Lisboa Central, Hospital de S\u00e3o Jos\u00e9 Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Rocha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Unidade Local Sa\u00fade Alto Minho Viana do Castelo Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Reis","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Hospital dos Marmeleiros Funchal Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Sarmento\u2010Castro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25062"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"e_1_2_8_4_1","unstructured":"Direc\u00e7\u00e3o Gerald a Sa\u00fade.Norma n\u00ba 028\/2017 de 28\/12\/2017 sobre o Tratamento da Hepatite C Cr\u00f3nica no Adulto.https:\/\/www.dgs.pt\/directrizes\u2010da\u2010dgs\/normas\u2010e\u2010circulares\u2010normativas\/norma\u2010n\u20100282017\u2010de\u201028122017\u2010pdf.aspx"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.016"},{"key":"e_1_2_8_6_1","unstructured":"http:\/\/www.who.int\/hepatitis\/news\u2010events\/WHO_Global\u2010Hepatitis. Infographic\u20101.gif?ua=1. Accessed January 2019."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.6"},{"key":"e_1_2_8_8_1","unstructured":"http:\/\/www.infarmed.pt\/documents\/15786\/1879176\/Tratamentos+para+hepatite+C+em+fases+mais+precoces++e+mais+de+dez+mil+doentes+curados\/2ba3b207\u2010c415\u20104f6d\u2010b2aa\u2010d8c635c97f47. Accessed January 2019."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1666841"},{"key":"e_1_2_8_10_1","unstructured":"Global Hepatitis Report 2017.http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/255016\/9789?sequence=1. Accessed January 2019."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0979-1"},{"issue":"5","key":"e_1_2_8_12_1","first-page":"498","article-title":"Liver fibrosis staging with combination of APRI and FIB\u20104 scoring systems in chronic hepatitis C as an alternative to transient elastography","volume":"32","author":"Papadopoulos N","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069153"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.13281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:45:33Z","timestamp":1693971933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/jvh.13281"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13281","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2020,3,11]]},"assertion":[{"value":"2019-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}