{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:00:07Z","timestamp":1756076407065,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2019R1A2C4070136"],"award-info":[{"award-number":["2019R1A2C4070136"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of tenofovir disoproxil fumarate (TDF) is associated with a risk of renal dysfunction. We investigated whether TDF is associated with the deterioration of renal function in patients with hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC) requiring frequent computed tomography (CT) evaluations and transarterial chemoembolization (TACE) sessions, when compared to entecavir (ETV). Between 2007 and 2017, 493 patients with HBV\u2010related HCC were enrolled. The number of CT evaluations and TACE sessions were collected through 3\u00a0years of follow\u2010up. The median age of the study population (373 men and 120 women; 325 with ETV and 168 with TDF) was 56.5\u00a0years. TDF was significantly associated with a serum creatinine increase (\u226525% from the baseline; unadjusted hazard ratio [uHR]\u00a0=\u00a01.620) and an estimated glomerular filtration rate (eGFR) reduction (&lt;20% from the baseline) (uHR\u00a0=\u00a01.950) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), when compared to ETV. In addition, CT evaluations\u00a0\u22654 times\/year were significantly associated with a serum creatinine increase (uHR\u00a0=\u00a02.709), eGFR reduction (uHR\u00a0=\u00a03.274) and chronic kidney disease (CKD) progression (\u22651 CKD stage from the baseline) (uHR\u00a0=\u00a01.980) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). In contrast, TACE was not associated with all renal dysfunction parameters (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). After adjustment, TDF use was independently associated with the increased risk of eGFR reduction (adjusted HR [aHR]\u00a0=\u00a01.945; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023), whereas CT evaluation \u22654 times\/year was independently associated with the increased risk of serum creatinine increase (aHR\u00a0=\u00a02.898), eGFR reduction (aHR\u00a0=\u00a03.484) and CKD progression (aHR\u00a0=\u00a01.984) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). In conclusion, patients with HBV\u2010related HCC treated with TDF and frequent CT evaluations should be closely monitored for the detection of associated renal dysfunction.<\/jats:p>","DOI":"10.1111\/jvh.13313","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T18:28:50Z","timestamp":1588616930000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Entecavir and tenofovir on renal function in patients with hepatitis B virus\u2010related hepatocellular carcinoma"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-4503","authenticated-orcid":false,"given":"Mi Young","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul South 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