{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:58Z","timestamp":1747186798077,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of multidrug\u2010resistant (MDR) chronic hepatitis B (CHB) is challenging. Herein, we report a multicenter prospective cohort study for the evaluation of tenofovir disoproxil fumarate (TDF)\u2010based therapy for MDR CHB in a real\u2010life setting. The inclusion criteria comprised patients with resistance to more than two nucleos(t)ide analogue (NA) classes and hepatitis B virus (HBV) DNA level of \u2265200\u00a0IU\/mL. The primary end\u2010point was virologic response (VR), defined as undetectable HBV DNA (&lt;20\u00a0IU\/mL) after 60\u00a0months. A total of 236 patients met the inclusion criteria. The mean HBV DNA level was 4.16\u00a0\u00b1\u00a01.44 log IU\/mL; 26.7% of patients had liver cirrhosis. Before the initiation of TDF, 33.5%, 44.9% and 21.6% of patients had mutations resistant to L\u2010NA\u00a0+\u00a0adefovir, L\u2010NA\u00a0+\u00a0entecavir (ETV) and L\u2010NA\u00a0+\u00a0adefovir\u00a0+\u00a0ETV, respectively. A total of 184 patients received TDF\u2010based combination therapy [TDF\u00a0+\u00a0ETV (n\u00a0=\u00a0178) or TDF\u00a0+\u00a0L\u2010NA (n\u00a0=\u00a06)], and 52 patients received TDF monotherapy. In the entire cohort, the VR rates were 77.2%, 89.9% and 92.2% at 12, 36 and 60\u00a0months, respectively. The VR rates were not significantly different between the combination therapy and the monotherapy group after 12 (76.2% vs 80.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.533), 36 (89.8% vs 90.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000) or 60 (92.9% vs 87.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.499) months. Also, there was no significant difference in the cumulative VR rates for 5\u00a0years between the treatment groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.910). Newly developed antiviral resistance was not observed. TDF\u2010based therapy was effective for the treatment of MDR CHB. The efficacy of TDF monotherapy was not different from that of the TDF\u2010based combination therapy.<\/jats:p>","DOI":"10.1111\/jvh.13363","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T13:40:35Z","timestamp":1595598035000},"page":"1306-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tenofovir\u2010based combination therapy or monotherapy for multidrug\u2010resistant chronic hepatitis B: Long\u2010term data from a multicenter cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-2754","authenticated-orcid":false,"given":"Hyung Joon","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University Medical College  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Jun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of 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