{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:26:46Z","timestamp":1790627206190,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in men who have sex with men (MSM) who have been exposed to pre\u2010exposure prophylaxis (PrEP) against HIV as sexual transmission of HEV has been suggested. A total of 147 PrEP\u2010using MSM and 147 blood donors matched for sex, age and geographical area were tested for anti\u2010HEV IgG and IgM. Among them, 135 have been followed for 1\u00a0year, at the end of which serological tests for HEV were performed retrospectively on stored samples. Laboratory data on sexual transmitted infections (STIs) and viral hepatitis, including hepatitis A virus (HAV), were collected. Baseline seroprevalence rates in PrEP users were 42.2% (anti\u2010HEV IgG) and 3.4% (anti\u2010HEV IgM). Those of the control blood donors were similar (anti\u2010HEV IgG 43.5% and anti\u2010HEV IgM 4.1%). There was no incident of HEV infection despite the rates of bacterial STIs (incidence rate (IR)\u00a0=\u00a046.6%) and HAV infection (IR\u00a0=\u00a015.8%). Age was the only risk factor associated with anti\u2010HEV IgG seropositivity at baseline and at the end of follow\u2010up. Sexual transmission does not seem to be a major route of HEV infection in MSM, unlike HAV.<\/jats:p>","DOI":"10.1111\/jvh.13367","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T15:45:00Z","timestamp":1596383100000},"page":"1495-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["No evidence of sexual transmission of HEV among individuals using HIV pre\u2010exposure prophylaxis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-3201","authenticated-orcid":false,"given":"Marion","family":"Migueres","sequence":"first","affiliation":[{"name":"Centre de Physiopathologie de Toulouse Purpan U1043 INSERM  Toulouse France"},{"name":"Laboratoire de virologie Centre National de R\u00e9f\u00e9rence H\u00e9patite E Institut F\u00e9d\u00e9ratif de Biologie CHU Toulouse H\u00f4pital Purpan  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eflys","family":"Ducours","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales CHU Bordeaux Groupe Hospitalier Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-4913","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Dimeglio","sequence":"additional","affiliation":[{"name":"Centre de Physiopathologie de Toulouse Purpan U1043 INSERM  Toulouse France"},{"name":"Laboratoire de virologie Centre National de R\u00e9f\u00e9rence H\u00e9patite E Institut F\u00e9d\u00e9ratif de Biologie CHU Toulouse H\u00f4pital Purpan  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Trimoulet","sequence":"additional","affiliation":[{"name":"Laboratoire de virologie CHU Bordeaux Groupe Hospitalier Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Abravanel","sequence":"additional","affiliation":[{"name":"Centre de Physiopathologie de Toulouse Purpan U1043 INSERM  Toulouse France"},{"name":"Laboratoire de virologie Centre National de R\u00e9f\u00e9rence H\u00e9patite E Institut F\u00e9d\u00e9ratif de Biologie CHU Toulouse H\u00f4pital Purpan  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Delobel","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales CHU Toulouse H\u00f4pital Purpan  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cazanave","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales CHU Bordeaux Groupe Hospitalier Pellegrin  Bordeaux France"},{"name":"Infections humaines \u00e0 mycoplasmes et \u00e0 chlamydiae Univ. 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