{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:08:11Z","timestamp":1791166091079,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB841"],"award-info":[{"award-number":["SFB841"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU Hepatitis"],"award-info":[{"award-number":["TTU Hepatitis"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In vitro cell culture experiments and animal models have demonstrated that hepatitis delta virus (HDV) can theoretically propagate being enveloped by human pathogenic viruses other than hepatitis B virus (HBV), namely hepatitis C virus (HCV) and dengue virus. However, the clinical relevance of these findings and whether HDV replication occurs in real\u2010world hepatitis B surface antigen (HBsAg)\u2013negative HCV patient cohorts remain unknown. To this aim, we analysed 323 HCV\u2010RNA\u2013positive and HBsAg\u2010negative sera for the presence of HDV\u2010RNA and anti\u2010HDV antibodies (anti\u2010HDV). All 323 (100%) samples were negative for HDV\u2010RNA. Interestingly, 8\/316 samples tested positive for anti\u2010HDV. The HBV serology of these eight patients showed a positive result for HBV core antibodies (anti\u2010HBc) indicating a seroconversion of an acute HBV infection in the past. None of the anti\u2010HBc\u2013negative patients were positive for anti\u2010HDV. Our results indicate a distinctly low probability of replicative HDV infection in HCV mono\u2010infected patients in Germany. Current German clinical guidelines rightly recommend performing HDV screening only in HBsAg\u2010positive patients. However, larger studies on this subject should be performed in regions that are endemic for chronic HBV\/HDV as well as HCV infections.<\/jats:p>","DOI":"10.1111\/jvh.13385","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T12:48:23Z","timestamp":1598532503000},"page":"213-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hepatitis delta virus propagation enabled by hepatitis C virus\u2014Scientifically intriguing, but is it relevant to clinical practice?"],"prefix":"10.1111","volume":"28","author":[{"given":"Lisa Sophie","family":"Pfl\u00fcger","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, I. Medical Department University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-1938","authenticated-orcid":false,"given":"Julian","family":"Schulze zur Wiesch","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, I. Medical Department University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Infection Research (DZIF) Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Polywka","sequence":"additional","affiliation":[{"name":"Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-7944","authenticated-orcid":false,"given":"Marc","family":"L\u00fctgehetmann","sequence":"additional","affiliation":[{"name":"Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Infection Research (DZIF) Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10117-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314713"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30922"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00014-19"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"e03250","article-title":"Snake deltavirus utilizes envelope proteins of different viruses to generate infectious particles","volume":"11","author":"Szirovicza L","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20455-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31453"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:59:19Z","timestamp":1693195159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,4]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jvh.13385"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13385","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,4]]},"assertion":[{"value":"2020-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}