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Direct\u2010acting antiviral (DAA) therapies offer clear benefits for liver\u2010related morbidity and mortality, and data from high\u2010income settings suggest that DAA treatments also provide significant benefits in terms of health\u2010related quality of life (HRQL). In this study, we assessed the effect of DAA treatment on HRQL for individuals treated for HCV in a clinical trial in Rwanda. We assessed the HRQL of participants using an 83\u2010question composite survey at Day 0 (\u2018baseline\u2019) and Week 24 (\u2018endpoint\u2019). Data were analysed in R. A total of 296 participants were included in this analysis. Their ages ranged from 19 to 90, and 184 (62.2%) were female. There were significant improvements from baseline to endpoint median scores for all physical and mental quality of life sub\u2010scales. Additionally, a reduction\u2014before and after treatment\u2014in the proportion of those classified as depressed and needing social support was statistically significant (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Economic productivity increased after treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and households classified as food secure increased from baseline to endpoint (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). These results demonstrate that Rwandans with chronic HCV infection experience both clinical and HRQL benefits, including household\u2010level benefits like substantial gains in workforce stability, economic productivity, and poverty alleviation, from DAA treatment. A stronger demonstration of accurate and broader household\u2010level benefits achieved through treatment of HCV with DAAs will help financing and investment for HCV in resource\u2010constrained settings become an urgent priority.<\/jats:p>","DOI":"10.1111\/jvh.13386","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:07:56Z","timestamp":1598670476000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved quality of life following direct\u2010acting antiviral treatment for chronic hepatitis C infection in Rwanda: Results from a clinical trial in sub\u2010Saharan Africa (the SHARED study)"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5167-5505","authenticated-orcid":false,"given":"Jennifer Ilo","family":"Van Nuil","sequence":"first","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Umutesi","sequence":"additional","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Shumbusho","sequence":"additional","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Kateera","sequence":"additional","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean de Dieu","family":"Dushimimana","sequence":"additional","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude Mambo","family":"Muvunyi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Musabeyezu","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"Mukabatsinda","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyprien","family":"Ntirenganya","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Kabahizi","sequence":"additional","affiliation":[{"name":"Rwanda Military Hospital  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janvier","family":"Serumondo","sequence":"additional","affiliation":[{"name":"Rwanda Biomedical Center  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-8844","authenticated-orcid":false,"given":"Jean Damascene","family":"Makuza","sequence":"additional","affiliation":[{"name":"Rwanda Biomedical Center  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabin","family":"Nsanzimana","sequence":"additional","affiliation":[{"name":"Rwanda Biomedical Center  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Grant","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Partners in Health  Rwinkwavu Rwanda"},{"name":"Department of Global Health and Social Medicine Harvard Medical School  Boston MA USA"},{"name":"Division of Global Health Equity Brigham and Women\u2019s Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global Hepatitis Report 2017.2017. doi:ISBN 978\u201092\u20104\u2010156545\u20105."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"issue":"145","key":"e_1_2_7_4_1","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: A systematic analysis","volume":"12","author":"Mokdad AA","year":"2014","journal-title":"BMC Med"},{"key":"e_1_2_7_5_1","unstructured":"International Agency for Research on Cancer.Estimated age\u2010standardized incidence rates (World) in 2018 Africa both sexes all ages. 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