{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:09:00Z","timestamp":1791288540238,"version":"4.3.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are accepted as first\u2010line treatments for chronic hepatitis B (CHB). However, there are few randomized studies comparing their efficacy. The primary aim of this study was to compare the efficacy of TDF and ETV using a network meta\u2010analysis of randomized trials. The secondary aim was to additionally include propensity\u2010matched cohort studies in a conventional meta\u2010analysis. We systematically searched PubMed, EMBASE, Cochrane Library and Web of Science for published English\u2010language randomized and propensity\u2010matched studies between 1\/1\/2000 and 4\/2\/2020. Outcomes included undetectable HBV DNA, ALT normalization and HBeAg seroconversion at 48\u00a0weeks. We excluded patients who had co\u2010infection or significant prior treatment with antivirals. 13\u00a0517 participants from 16 studies (11 RCTs, n\u00a0=\u00a02675; five propensity\u2010matched cohort studies, n\u00a0=\u00a010\u00a0842) were included. Virological response at 48\u00a0weeks was higher in patients receiving TDF compared to ETV using both the network meta\u2010analytic approach (OR 1.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and the conventional meta\u2010analysis including propensity\u2010matched cohort studies (OR 1.40, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). On subgroup analysis, this difference was only significant in HBeAg\u2010positive patients (OR 1.81, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.037). There was limited evidence to suggest a higher rate of ALT normalization with ETV (OR 0.74, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.07). There was no difference in rates of HBeAg seroconversion between the two antivirals. TDF is more likely than ETV to induce virological response at 48\u00a0weeks in treatment\u2010na\u00efve CHB patients. Future studies should focus on elucidating associations between early and sustained virological response with adverse patient outcomes including development of HCC or cirrhosis.<\/jats:p>","DOI":"10.1111\/jvh.13400","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:15:21Z","timestamp":1600780521000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of 48\u2010week efficacy of tenofovir vs entecavir for patients with chronic hepatitis B: A network meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6103","authenticated-orcid":false,"given":"Danny","family":"Con","sequence":"first","affiliation":[{"name":"Department of General Medicine Eastern Health Melbourne Victoria 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