{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:52:39Z","timestamp":1777942359713,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2019R1A2C4070136"],"award-info":[{"award-number":["2019R1A2C4070136"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several prediction scores for the early detection of hepatocellular carcinoma (HCC) are available. We validated the predictive accuracy of age, albumin, sex, liver cirrhosis (AASL), RESCUE\u2010B, PAGE\u2010B and modified PAGE\u2010B (mPAGE\u2010B) scores in chronic hepatitis B (CHB) patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF). Between 2007 and 2014, 3171 patients were recruited (1645, ETV; 1517, TDF). The predictive accuracy of each prediction score was assessed. The mean age of the study population (1977 men; 1194 women) was 48.8\u00a0years. Liver cirrhosis was present in 1040 (32.8%) patients. During follow\u2010up (median, 58.2\u00a0months), 280 (8.8%) patients developed HCC; these patients were significantly older; more likely to be male; had significantly higher proportions of liver cirrhosis, hypertension and diabetes; and had significantly higher values for the four risk scores than those who did not develop HCC (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Older age (hazard ratio [HR]\u00a0=\u00a01.048), male sex (HR\u00a0=\u00a02.142), liver cirrhosis (HR\u00a0=\u00a03.144) and prolonged prothrombin time (HR\u00a0=\u00a02.589) were independently associated with an increased risk of HCC (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), whereas a higher platelet count (HR\u00a0=\u00a00.996) was independently associated with a decreased risk of HCC (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The predictive accuracy of AASL score was the highest for 3\u2010 and 5\u2010year HCC predictions (areas under the curve [AUCs]\u00a0=\u00a00.818 and 0.816, respectively), followed by RESCUE\u2010B, PAGE\u2010B and mPAGE\u2010B scores (AUC\u00a0=\u00a00.780\u20100.815 and 0.769\u20100.814, respectively). In conclusion, four HCC prediction scores were assessed in Korean CHB patients treated with ETV or TDF. The AASL score showed the highest predictive accuracy.<\/jats:p>","DOI":"10.1111\/jvh.13411","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:56:42Z","timestamp":1602136602000},"page":"95-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Validation of risk prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with entecavir or tenofovir"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9142-7111","authenticated-orcid":false,"given":"Jin Won","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul 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