{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:40:03Z","timestamp":1747186803648,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term use of tenofovir disoproxil fumarate (TDF) can induce renal dysfunction that requires TDF dose reduction. Previous studies showed that systemic drug use exerts a threefold higher risk of moderate renal impairment. This study aimed to compare viral control between two tenofovir dose reduction regimens in chronic hepatitis B (CHB) patients with moderate renal impairment from TDF\u2010induced renal dysfunction. This noninferiority, randomized controlled study was conducted at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Virologically suppressed CHB patients treated with TDF who had moderate renal impairment were randomly allocated to receive TDF 300\u00a0mg either every 48 or 72\u00a0hours. Forty\u2010six patients (67.4% male) with a mean age of 62.8\u00a0\u00b1\u00a07.8\u00a0years were enrolled. Among all patients, 34.8% were HBeAg\u2010positive, and 23.9% had cirrhosis. All included patients completed 12\u00a0months of follow\u2010up. No patients had virological breakthrough. After dose reduction, estimated glomerular filtration rate (eGFR) was improved in both groups, but a higher proportion of patients had an eGFR\u00a0&gt;\u00a060\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> in the TDF every 72\u00a0hours group. Other renal parameters, including serum phosphate, tubular maximal reabsorption for phosphate per GFR, urine protein\u2010to\u2010creatinine ratio, urine sugar and urine neutrophil gelatinase\u2010associated lipocalin, were not significantly different between groups. Among TDF\u2010treated CHB patients with TDF\u2010induced moderate renal impairment, more aggressive dose reduction in TDF from every 48\u00a0hours to every 72\u00a0hours did not affect virological breakthrough. A higher proportion of patients in the TDF every 72\u00a0hours group had improvement in renal function.<\/jats:p>","DOI":"10.1111\/jvh.13420","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T03:05:21Z","timestamp":1602558321000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of viral control between two tenofovir dose reduction regimens (300\u00a0mg every 48 hours versus 300\u00a0mg every 72 hours) in chronic hepatitis B patients with moderate renal impairment from tenofovir\u2010induced renal dysfunction"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-4180","authenticated-orcid":false,"given":"Watcharasak","family":"Chotiyaputta","sequence":"first","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital Division of Gastroenterology Department of Medicine Mahidol University Bangkok 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