{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:58:47Z","timestamp":1768280327224,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral Direct\u2010acting antivirals (DAAs) are safe, highly effective altering disease burden and prognosis in hepatitis C patients. Sustained virologic response (SVR) is achieved nowadays in more than 90% of the treated patients and related to the improvements in functions of the liver, fibrosis plus survival. Furthermore, portal hypertension is thought to be improved with achievement of virological response, parallel to the improvements in hepatic inflammation and fibrosis. We aimed to assess the recurrence rate of oesophageal varices by long\u2010term follow\u2010up in patients treated with different DAAs regimens who had achieved SVR. We studied 176 Child A cirrhotic HCV patients who achieved SVR after DAAs treatment and had a history of endoscopic oesophageal varices obliteration and were on maximum tolerated propranolol dose. They were subjected to follow\u2010up upper gastrointestinal endoscopy repeated every 6\u00a0months for 4\u00a0years. Fifty\u2010two patients (29.5%) had recurrence of oesophageal varices observed during the 4\u2010years follow\u2010up upper GIT endoscopy. On multivariate analysis, platelet count was the only significant variable, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.007*. HbA1C, HOMA IR, BMI 1 and BMI 2 showed non\u2010significant differences between the studied groups. By ROC analysis, we identified baseline platelet count of 96\u00a0000\/\u00b5L with 100% sensitivity (95% confidence interval [CI] [91%\u2010100%]) and 74% specificity (95% CI [65%\u201081%]). Spearman correlation showed a positive correlation between AFP, age, AST, Bilirubin, creatinine, INR. Patients who achieved SVR post DAAs showed a significant decrease in oesophageal varices recurrence post endoscopic obliteration. Baseline platelet count was found to be a strong independent predictor for oesophageal varices recurrence.<\/jats:p>","DOI":"10.1111\/jvh.13426","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T02:40:47Z","timestamp":1603507247000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variceal recurrence 4\u00a0years post endoscopic band ligation in hepatitis C patients who achieved sustained virological response with oral direct\u2010acting antiviral therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"El\u2010Sayed","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology National Liver Institute Menoufia University  Menoufia 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