{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:45Z","timestamp":1793060025116,"version":"4.5.0"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to define the therapeutic range for ribavirin (RBV) in transplant recipients with chronic hepatitis E virus (HEV) infection. In this retrospective multicentre cohort study, data of adult transplant recipients with chronic HEV infection, who had been treated with RBV monotherapy between 01\u20103\u20102008 and 01\u201008\u20102018, were included. ROC curve analyses were performed, and the half\u2010maximal effective RBV concentration was calculated to determine a representative therapeutic range. In 96 patients, RBV monotherapy for a median of three months resulted in a sustained virologic response in 63.5% of the patients, while 88.5% of the patients developed anaemia. RBV plasma concentrations at steady state were significantly higher in clinical responders compared with clinical non\u2010responders: median 1.96 (IQR 1.81\u20102.70) versus 0.49 (IQR 0.45\u20100.73) mg\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0004. RBV caused a dose\u2010dependent haemoglobin reduction with higher RBV plasma concentrations resulting in more haemoglobin reduction. The therapeutic range for RBV for chronic HEV infection in transplant recipients ranges between 1.8 and 2.3\u00a0mg\/L.<\/jats:p>","DOI":"10.1111\/jvh.13432","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T04:50:50Z","timestamp":1604292650000},"page":"431-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determining the therapeutic range for ribavirin in transplant recipients with chronic hepatitis E virus infection"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-3771","authenticated-orcid":false,"given":"Midas B.","family":"Mulder","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-8964","authenticated-orcid":false,"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organs Transplantation CHU Rangueil INSERM U1043 IFR\u2013BMT Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u0171lcan","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep","family":"de Bruijne","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Medical Center Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-8741","authenticated-orcid":false,"given":"Thomas","family":"Vanwolleghem","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Antwerp Edegem Belgium"},{"name":"Laboratory of Experimental Medicine and Pediatrics University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3234","authenticated-orcid":false,"given":"Jacques","family":"Izopet","sequence":"additional","affiliation":[{"name":"Department of Virology CHU Purpan INSERM U1043 IFR\u2013BMT University Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-7894","authenticated-orcid":false,"given":"Peggy","family":"Gandia","sequence":"additional","affiliation":[{"name":"Department of Toxicology CHU Purpan 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-1962","authenticated-orcid":false,"given":"Dennis A.","family":"Hesselink","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology and Transplantation Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-8443","authenticated-orcid":false,"given":"Brenda C.M.","family":"de Winter","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC University Medical Center Rotterdam Rotterdam The 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