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Patients with SARS\u2010CoV\u20102 infection and no antecedent liver disease may display evidence of cytolytic liver damage, proportional to the severity of COVID\u201019 but rarely of clinical significance. The mechanism of hepatocellular injury is unclear and possibly multifactorial. The clinical impact of SARS\u2010CoV\u20102 infection in patients with underlying chronic liver disease, a cohort whose global size is difficult to estimate, has been assessed appropriately only recently and data are still evolving. Patients with cirrhosis are at higher risk of developing severe COVID\u201019 and worse liver\u2010related outcomes as compared to those with non\u2010cirrhotic liver disease. OLT patients have an intermediate risk. Specific interventions in order to reduce the risk of transmission of infection among this high\u2010risk population have been outlined by international societies, together with recommendations for modified treatment and follow\u2010up regimens during the COVID\u201019 pandemic. When a vaccine against SARS\u2010CoV\u20102 becomes available, patients with fibrotic liver disease and those with OLT should be considered as prime targets for prophylaxis of COVID\u201019, as all other highly susceptible subjects.<\/jats:p>","DOI":"10.1111\/jvh.13440","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T16:30:21Z","timestamp":1605457821000},"page":"4-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["SARS\u2010CoV\u20102 infection in patients with a normal or abnormal liver"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-3859","authenticated-orcid":false,"given":"Giuseppe","family":"Cabibbo","sequence":"first","affiliation":[{"name":"Section of Gastroenterology and Hepatology Department of Health Promotion, Mother and Child Care Internal Medicine and Medical Specialties PROMISE University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-6740","authenticated-orcid":false,"given":"Giacomo Emanuele Maria","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Department of Health Promotion, Mother and Child Care Internal Medicine and Medical Specialties PROMISE University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-6834","authenticated-orcid":false,"given":"Caterina","family":"Stornello","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Department of Health Promotion, Mother and Child Care Internal Medicine and Medical Specialties PROMISE University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-9544","authenticated-orcid":false,"given":"Antonio","family":"Crax\u00ec","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Department of Health Promotion, Mother and Child Care Internal Medicine and Medical Specialties PROMISE University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_8_3_1","unstructured":"Data from Center for System Science and Engineering (CSSE) at Johns Hopkins University. 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