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The Canadian Hepatitis B Network Cohort was utilized to conduct a cross\u2010sectional evaluation of the demographic, biochemical, fibrotic and treatment characteristics of HIV\u2010HBV patients and a comparator HBV group. From a total of 5996 HBV\u2010infected patients, 335 HIV\u2010HBV patients were identified. HIV\u2010HBV patients were characterized by older median age, higher male and lower Asian proportion, more advanced fibrosis and higher anti\u2010HBV therapy use (91% vs. 30%) than the HBV\u2010positive \/ HIV seronegative comparator group. A history of reported high\u2010risk exposure activities (drug use, high\u2010risk sexual contact) was more common in HIV\u2010HBV patients. HIV\u2010HBV patients with reported high\u2010risk exposure activities had higher male proportion, more Caucasian ethnicity and higher prevalence of cirrhosis than HIV\u2010HBV patients born in an endemic country. In the main cohort, age \u226560\u00a0years, male sex, elevated ALT, the presence of comorbidity and HCV seropositivity were independent predictors of significant fibrosis. HIV seropositivity was not an independent predictor of advanced fibrosis (adj OR 0.75 [95%CI: 0.34\u20131.67]). In conclusion, Canadian co\u2010infected patients differed considerably from those with mono\u2010infection. Furthermore, HIV\u2010HBV\u2010infected patients who report high\u2010risk behaviours and those born in endemic countries represent two distinct subpopulations, which should be considered when engaging these patients in care.<\/jats:p>","DOI":"10.1111\/jvh.13453","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T17:27:59Z","timestamp":1607707679000},"page":"517-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Distinct Hepatitis B and HIV co\u2010infected populations in Canada"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-3499","authenticated-orcid":false,"given":"Curtis","family":"Cooper","sequence":"first","affiliation":[{"name":"University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Driedger","sequence":"additional","affiliation":[{"name":"University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wong","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-870X","authenticated-orcid":false,"given":"Sarah","family":"Haylock\u2010Jacobs","sequence":"additional","affiliation":[{"name":"University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel","family":"Aziz Shaheen","sequence":"additional","affiliation":[{"name":"University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Osiowy","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Fung","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Doucette","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Wong","sequence":"additional","affiliation":[{"name":"University of Saskatchewan Regina Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Barrett","sequence":"additional","affiliation":[{"name":"Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Conway","sequence":"additional","affiliation":[{"name":"Vancouver Infectious Disease Centre Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alnoor","family":"Ramji","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-940X","authenticated-orcid":false,"given":"Gerald","family":"Minuk","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Wong","sequence":"additional","affiliation":[{"name":"McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla S.","family":"Coffin","sequence":"additional","affiliation":[{"name":"University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.12.116"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021410"},{"key":"e_1_2_6_4_1","unstructured":"UNAIDS.Global HIV & AIDS Statistics \u2010 2019 Fact Sheet. 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