{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:05:48Z","timestamp":1787069148176,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In routine clinical practice, hepatitis C virus\u2010infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE\u2010Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5\u00a0years, and 53 (14.5%) patients were HIV\u2010co\u2010infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0168, 46%) and 3 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a059, 16.2%). DAA was discontinued a median of 1 (IQR 1\u20134) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2\u00a0weeks before the planned schedule. In patients with F0\u2013F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for &lt;4\u00a0weeks: 50% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02\/4) vs. 99.1% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0109\/110) for \u22654\u00a0weeks,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated &lt;8\u00a0weeks: 83.3% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a025\/30) vs. 94.6% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0209\/221) for \u22658\u00a0weeks,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real\u2010life setting for treatment lasting at least 4\u00a0weeks in patients with liver fibrosis F0\u2013F3 and 8\u00a0weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13454","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T11:30:10Z","timestamp":1607686210000},"page":"558-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV\u2010infected patients treated in a real\u2010life setting"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-812X","authenticated-orcid":false,"given":"Massimiliano","family":"Fabbiani","sequence":"first","affiliation":[{"name":"U.O. Malattie Infettive e Tropicali Fondazione IRCCS Policlinico San Matteo Pavia Italy"},{"name":"UOC Malattie Infettive e Tropicali Azienda Ospedaliero\u2010Universitaria Senese Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-9579","authenticated-orcid":false,"given":"Andrea","family":"Lombardi","sequence":"additional","affiliation":[{"name":"U.O. Malattie Infettive e Tropicali Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Colaneri","sequence":"additional","affiliation":[{"name":"U.O. Malattie Infettive e Tropicali Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Del Poggio","sequence":"additional","affiliation":[{"name":"Divisione di Medicina Policlinico San Pietro Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Perini","sequence":"additional","affiliation":[{"name":"Divisione di Medicina Policlinico San Pietro Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"UOC Gastroenterologia ed Epatologia CRC \u2018AM e A Migliavacca\u2019 per lo studio e la cura delle malattie del fegato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-4669","authenticated-orcid":false,"given":"Elisabetta","family":"Degasperi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"UOC Gastroenterologia ed Epatologia CRC \u2018AM e A Migliavacca\u2019 per lo studio e la cura delle malattie del fegato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Dibenedetto","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Epatologia e Gastroenterologia Ospedale San Paolo Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giorgini","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Epatologia e Gastroenterologia Ospedale San Paolo Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Pasulo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Gastroenterologia ASST Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Maggiolo","sequence":"additional","affiliation":[{"name":"U.O. Malattie Infettive ASST Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Castelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Infettive Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Brambilla","sequence":"additional","affiliation":[{"name":"U.O. Malattie Infettive Istituti Ospitalieri Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Spinelli","sequence":"additional","affiliation":[{"name":"UO Medicina Interna Cant\u00f9 ASST LARIANA Como Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Re","sequence":"additional","affiliation":[{"name":"U.O. Malattie Infettive ASST Ovest Milanese Legnano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lleo","sequence":"additional","affiliation":[{"name":"Medicina Interna ed Epatologia Humanitas Clinical and Research Center\u2014IRCCS Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Rumi","sequence":"additional","affiliation":[{"name":"U.O. Epatologia Ospedale San Giuseppe Multimedica Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Uberti\u2010Foppa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Vita\u2010Salute San Raffaele University Milan Milan Italy"},{"name":"Division of Infectious Diseases IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Soria","sequence":"additional","affiliation":[{"name":"UO Malattie Infettive Ospedale San Gerardo ASST Monza Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Aghemo","sequence":"additional","affiliation":[{"name":"Medicina Interna ed Epatologia Humanitas Clinical and Research Center\u2014IRCCS Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-7476","authenticated-orcid":false,"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"UOC Gastroenterologia ed Epatologia CRC \u2018AM e A Migliavacca\u2019 per lo studio e la cura delle malattie del fegato Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Baiguera","sequence":"additional","affiliation":[{"name":"UO Malattie Infettive ASST Grande Ospedale Metropolitano Niguarda Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Schiavini","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Infettive Ospedale Luigi Sacco Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fagiuoli","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Gastroenterologia ASST Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Bruno","sequence":"additional","affiliation":[{"name":"U.O. 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of Viral 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