{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:40:17Z","timestamp":1761061217481,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir\/sofosbuvir (LDV\/SOF). The relationship between PPI usage and SVR is less clear in patients with HIV\/HCV coinfection, where concomitant antiretrovirals may result in more complex drug interactions. This retrospective study evaluates the effects of acid suppression medications (PPI or H<jats:sub>2<\/jats:sub>\u2010receptor antagonist [H<jats:sub>2<\/jats:sub>B]) use and SVR rates in patients with HIV\/HCV or HCV and taking LDV\/SOF in a large multicentre veteran cohort. Patients in the Veterans Affairs Health Care System who received LDV\/SOF \u00b1 ribavirin from 10\/10\/2014 to 12\/31\/2015 were included. The odds ratios (OR) of PPI or H<jats:sub>2<\/jats:sub>B use for SVR were adjusted for clinical factors and with inverse probability of treatment weighting for non\u2010random treatment selection for acid suppression medication use. There were 9703 veterans included in our final analysis. After adjustment of other clinical factors, PPI use is associated with a lower SVR in the overall cohort (95.0% vs. 96.1%, OR: 0.86, 95% CI: 0.74\u20130.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03, number needed to harm 90.9) and HIV\/HCV coinfection subgroup (93.4% vs. 96.9%, OR: 0.47, 95% CI: 0.26\u20130.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01, number needed to harm 28.6). This present study reveals PPI use is associated with reduced SVR after LDV\/SOF treatment, with a more significant impact in the subgroup of patients with HIV\/HCV coinfection. Precautions need to be taken when using PPI and LDV\/SOF in this group of patients.<\/jats:p>","DOI":"10.1111\/jvh.13462","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T01:09:08Z","timestamp":1609376948000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV\/HCV coinfection on ledipasvir\/sofosbuvir: a real\u2010world study from a multicentre VA cohort"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-3447","authenticated-orcid":false,"given":"Tzu\u2010Hao","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine Durham NC USA"},{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine Morehouse School of Medicine Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Bryan","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Park","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"},{"name":"Division of infectious diseases Department of Medicine Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Hashem","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Townsend","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Moylan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine Durham NC USA"},{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Britt","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Duke University School of Medicine Durham NC USA"},{"name":"Durham Veterans Affairs Health Care System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Naggie","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System Durham NC USA"},{"name":"Division of infectious diseases Department of Medicine Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00485-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032653"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.23.2839"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29308"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ438"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501315"},{"key":"e_1_2_10_9_1","unstructured":"GermanP HanL SajwaniK.Drug interactions between direct acting anti\u2010HCV antivirals sofosbuvir and ledipasvir and HIV antiretrovirals. 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