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However, drug resistance may occur as a result of long\u2010term treatment, and continuous covalently closed circular DNA (cccDNA) can cause disease relapse after drug withdrawal. Therefore, there is an urgent need for safe and effective antiviral drugs or methods to treat HBV and HDV infections. Myrcludex B is the first entry inhibitor that can inactivate HBV and HDV receptors, compete with HBV for the sodium\u2010taurocholate co\u2010transporting polypeptide, which has been identified as the <jats:italic>bona fide<\/jats:italic> receptor for HBV and HDV, block HBV infection in hepatocytes, and participate in HBV transcriptional suppression. Myrcludex B plays an important role in the inhibition of HBV replication and is a potential drug for phase III clinical trials. In this article, we review the progress on the efficacy and clinical application of myrcludex B in recent years.<\/jats:p>","DOI":"10.1111\/jvh.13490","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T06:57:28Z","timestamp":1613631448000},"page":"852-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Clinical effects of NTCP\u2010inhibitor myrcludex B"],"prefix":"10.1111","volume":"28","author":[{"given":"Dongliang","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Pharmacy Guilin Medical University  Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guilin Medical University  Guilin Guangxi 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