{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:10:13Z","timestamp":1772993413854,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work evaluates the potential impact at territorial level of the Strategic Plan for Tackling Hepatitis C in the Spanish National Health System on hepatitis C virus (HCV)\u2010associated hospitalizations. Chronic HCV\u2010related hospitalization discharges from 2014 to 2018 were obtained from the National Registry of Hospitalisations. A descriptive analysis of the hospitalizations was performed for all chronic, advanced liver disease and non\u2010advanced liver disease. Hospitalization rates were calculated at national and regional level. Year 2015 and period 2016\u20132018 hospitalization rates were compared to 2014 hospitalization rates using a Poisson model. Municipal standardized hospitalization rates ratios adjusted by age\u2010group were calculated for 2016\u20132018 period (2014 hospitalization rates as reference). From 2014 to 2018, there were 22,352 chronic HCV\u2010related hospitalizations. In\u2010hospital fatality rate was 4.3% for non\u2010advanced liver disease and 11.7% for advanced liver disease patients. National hospitalization rate decreased 22% (95% CI: 21%\u201322%), 16% (95% CI: 15%\u201317%) and 34% (95% CI: 33%\u201335%) in 2016\u20132018 compared to 2014 for all chronic, non\u2010advanced and advanced liver disease, respectively. During 2016\u20132018 period, 11\/19 Spanish regions achieved &gt;20% decrease in the hospitalization rates (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) for non\u2010advanced liver disease and 19\/19 (except Melilla, the rest with <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) for advanced liver disease. At municipal level, 84.8% and 90.2% municipalities had &lt;20% of chronic HCV\u2010related hospitalization need compared to 2014 adjusted by age\u2010group. Based on the data analysed, a high impact on reducing chronic HCV\u2010associated hospitalizations have been achieved after the implementation of the Strategic Plan for Tackling Hepatitis C in the Spanish National Health System. However, small differences between regions and rural\/urban areas were noticed.<\/jats:p>","DOI":"10.1111\/jvh.13491","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T13:24:53Z","timestamp":1613654693000},"page":"859-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduction in hepatitis C\u2010related hospitalizations after the implementation of the Strategic Plan for Tackling Hepatitis C in the Spanish National Health System: regional level differences"],"prefix":"10.1111","volume":"28","author":[{"given":"Juan Jos\u00e9","family":"Vegas","sequence":"first","affiliation":[{"name":"TRAGSA Group  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Flores\u2010Herrera","sequence":"additional","affiliation":[{"name":"Emergencies Coordination Centre Madrid Region Emergency Medical Service (SUMMA 112)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pello","family":"Latasa","sequence":"additional","affiliation":[{"name":"Ministry of Health  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-3823","authenticated-orcid":false,"given":"Macarena","family":"Garrido\u2010Estepa","sequence":"additional","affiliation":[{"name":"Ministry of Science and Innovation  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3061"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0748-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29814"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0624-6"},{"key":"e_1_2_12_6_1","unstructured":"WHO.Combating Hepatitis B and C to reach elimination by 2030[Internet];2016.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/206453\/WHO_HIV_2016.04_eng.pdf;jsessionid=6095A6CC78F9B4BDEE274A340EAC2885?sequence=1. 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