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We prospectively compared the estimated glomerular filtration rate (eGFR) changes in 167 patients receiving SOF\u2010based direct\u2010acting antivirals (DAAs) who also received tenofovir disoproxil fumarate (TFV)\u2010based (<jats:italic>n<\/jats:italic>\u00a0=\u00a0116) and TFV\u2010free ART (<jats:italic>n<\/jats:italic>\u00a0=\u00a051). The eGFR was assessed by the Chronic Kidney Disease Epidemiology Collaboration (CKD\u2010EPI) equation, and the eGFR changes between ART regimens were compared by the generalized estimated equation. During DAA treatment, participants on TFV\u2010based ART had a higher eGFR decline than those on TFV\u2010free ART (slope coefficient difference: \u22120.82\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month [95% CI: \u22121.21 to \u22120.43]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), whereas the eGFR changes did not differ between groups (slope coefficient difference: 0.13\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month [95% CI: \u22120.32 to 0.58]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.42) after discontinuing DAAs. Participants on TFV TDF\u2010based ART had a higher eGFR decline than those on TFV alafenamide fumarate (TAF)\u2010based ART (slope coefficient difference: \u22120.31\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month [95% CI: \u22120.50 to \u22120.12]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). After discontinuing DAAs, the eGFR changes did not differ between groups (slope coefficient difference: 0.06\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/month [95% CI: \u22120.98 to 1.10]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.91). In conclusion, HIV\/HCV\u2010coinfected patients on TFV\u2010based ART had a slight eGFR decline compared to those on TFV\u2010free ART during SOF\u2010based DAA therapy. A similar trend between TDF\u2010based and TAF\u2010based ART was also observed. Because the differences of eGFR changes are limited, the physicians should not discourage the use of SOF\u2010based DAAs in HIV\u2010positive patients on TFV\u2010based ART.<\/jats:p>","DOI":"10.1111\/jvh.13502","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T08:11:26Z","timestamp":1616573486000},"page":"887-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evolution of estimated glomerular filtration rate in human immunodeficiency virus and hepatitis C virus\u2010coinfected patients receiving sofosbuvir\u2010based direct\u2010acting antivirals and antiretroviral therapy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"Chen\u2010Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai\u2010Chung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jer","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Ching","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of 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