{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:24:03Z","timestamp":1757456643952,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CAGE\u2010B and SAGE\u2010B scores, consisting of age and fibrotic burden as cirrhosis and\/or liver stiffness, were recently proposed to predict hepatocellular carcinoma (HCC) risk among Caucasian chronic hepatitis B (CHB) patients undergoing long\u2010term antiviral therapy. We externally validated their predictive performances among an independent cohort from Asia, compared to other conventional prediction models. We consecutively recruited CHB patients with well\u2010controlled viremia (serum HBV DNA\u00a0&lt;\u00a02000\u00a0IU\/mL) receiving antiviral therapy. Patients with decompensated cirrhosis or HCC at baseline were excluded. Among 1763 patients, CAGE\u2010B score provided the highest Heagerty's integrated area under the curve (iAUC) (0.820), followed by SAGE\u2010B (0.804), mREACH\u2010B (0.800), CAMD (0.786), mPAGE\u2010B (0.748) and PAGE\u2010B (0.721) scores. CAGE\u2010B score showed a significantly better performance than SAGE\u2010B, CAMD, PAGE\u2010B and mPAGE\u2010B scores, but was similar to mREACH\u2010B. SAGE\u2010B score also showed significantly better performance than mPAGE\u2010B and PAGE\u2010B, but was similar to CAMD and mREACH\u2010B. According to CAGE\u2010B score 0\u20135, 6\u201310 and \u226511, the annual HCC incidences were 0.18, 1.34 and 6.03 per 100 person\u2010years, respectively (all <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001 between each pair). Likewise, by SAGE\u2010B score 0\u20135, 6\u201310 and \u226511, those were 0.31, 1.49 and 8.96 per 100 person\u2010years, respectively (all <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001 between each pair). Hence, CAGE\u2010B and SAGE\u2010B scores showed acceptable predictive performances for Asian CHB patients undergoing antiviral therapy, with the higher performance by CAGE\u2010B score. They show a trend towards better prognostic capability to predict HCC risk than previous models.<\/jats:p>","DOI":"10.1111\/jvh.13506","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T06:50:15Z","timestamp":1616655015000},"page":"951-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["External validation of CAGE\u2010B and SAGE\u2010B scores for Asian chronic hepatitis B patients with well\u2010controlled viremia by antivirals"],"prefix":"10.1111","volume":"28","author":[{"given":"Jung Hyun","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Internal medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine Daegu 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