{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:37:47Z","timestamp":1790667467956,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. However, host\u2013HEV interactions have yet to be fully understood. Zinc\u2010finger antiviral protein (ZAP) is a novel interferon (IFN)\u2010stimulated gene product that inhibits a variety of viruses in synergy with IFN\u2010\u03b2. To evaluate the role of ZAP in HEV infection, its expressions in HEV\u2010infected patients and in cell cultures were measured. We report a significant inhibition of ZAP expression in patients with HEV genotype four acute infection. The expression of ZAP in the HEV life cycle was monitored in cultures of HEV\u2010infected cells. Results indicated that the ZAP level decreased significantly after HEV infection. ZAP over\u2010expression inhibited HEV replication, whereas its knockdown by RNA interference significantly increased HEV RNA. These suggest that ZAP serves as an antiviral in HEV infection. Moreover, silencing ZAP decreased IFN regulatory factor 3 (IRF3) phosphorylation in HEV\u2010infected cells treated with poly(I:C), indicating that ZAP synergizes with IFN\u2010\u03b2. In conclusion, ZAP is an important anti\u2010HEV host factor and in synergy with IFN\u2010\u03b2, inhibits HEV replication.<\/jats:p>","DOI":"10.1111\/jvh.13522","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T13:40:00Z","timestamp":1619271600000},"page":"1219-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of hepatitis E virus replication by zinc\u2010finger antiviral Protein synergizes with IFN\u2010\u03b2"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-7199","authenticated-orcid":false,"given":"Wenhai","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbin","family":"Ji","sequence":"additional","affiliation":[{"name":"Medical 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