{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:21:42Z","timestamp":1790698902666,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Real\u2010world evidence on the course of Hepatitis C Virus (HCV) chronic liver disease after Sustained Virologic Response (SVR) obtained with direct\u2010acting antiviral drugs (DAAs) are still limited, and the effects on mortality remain unclear. We evaluated the post\u2010treatment survival of 4307 patients in the RESIST\u2010HCV cohort (mean age 66.3\u00a0\u00b1\u00a011.6\u00a0years, 56.9% males, 24.7% chronic hepatitis, 66.9% Child\u2010Pugh A cirrhosis and 8.4% Child\u2010Pugh B cirrhosis) treated with DAAs between March 2015 and December 2016 and followed for a median of 73\u00a0weeks (range 16\u2013152). Proportional cause\u2010specific hazard regression for competing risks was used to evaluate the survival and to assess the predictors of liver and cardiovascular death. Overall, 94.7% of patients achieved SVR while 5.3% were HCV RNA\u2010positive at last follow\u2010up. Sixty\u2010three patients (1.4%) died during the observation period. SVR was associated with a decreased risk of liver mortality (hazard ratio,HR0.09, beta \u22122.37,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a0.001). Also, platelet count (HR 0.99, beta\u20100.01,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a0.007) and albumin value (HR 0.26, beta \u22121.36\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a0.001) were associated with liver mortality by competing risk analysis. SVR was associated with a reduced risk of cardiovascular mortality regardless of presence of cirrhosis (HR 0.07, beta\u20102.67,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a0.001). Presence of diabetes (HR 3.45, beta 1.24,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a0.014) and chronic kidney disease class \u22653 (HR 3.60, beta 1.28,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.016) were two factors independently associated with higher risk of cardiovascular mortality. Patients with SVR to a DAA therapy have a better liver and cardiovascular survival, and the effects of HCV eradication are most evident in patients with compensated liver disease.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13523","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T03:21:31Z","timestamp":1619320891000},"page":"1190-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Liver and cardiovascular mortality after hepatitis C virus eradication by DAA: Data from RESIST\u2010HCV cohort"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-1059","authenticated-orcid":false,"given":"Vincenza","family":"Calvaruso","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Unit Department of Health Promotion Sciences Maternal and Infantile Care Internal Medicine and Medical Specialities PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Petta","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit Department of Health Promotion Sciences Maternal and Infantile Care Internal Medicine and Medical Specialities PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-6799","authenticated-orcid":false,"given":"Irene","family":"Cacciola","sequence":"additional","affiliation":[{"name":"UOC Epatologia Clinica e Biomolecolare  Messina Italy"},{"name":"AOUP G. Martino Dipartimento di Medicina Interna e Sperimentale University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cabibbo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit Department of Health Promotion Sciences Maternal and Infantile Care Internal Medicine and Medical Specialities PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cartabellotta","sequence":"additional","affiliation":[{"name":"UOC Medicina Interna Ospedale Buccheri La Ferla  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Distefano","sequence":"additional","affiliation":[{"name":"UOC Malattie Infettive Ospedale Umberto I di Siracusa ASP Siracusa  Siracusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Scifo","sequence":"additional","affiliation":[{"name":"UOC Malattie Infettive Ospedale Umberto I di Siracusa ASP Siracusa  Siracusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"Di Rosolini","sequence":"additional","affiliation":[{"name":"UOC Malattie Infettive Ospedale Maggiore di Modica  Modica Italy"},{"name":"ASP Ragusa  Ragusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Russello","sequence":"additional","affiliation":[{"name":"UOS Epatologia ARNAS Garibaldi\u2010Nesima  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Prestileo","sequence":"additional","affiliation":[{"name":"UOC Malattie Infettive ARNAS Civico\u2010Di Cristina\u2010Benefratelli  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Madonia","sequence":"additional","affiliation":[{"name":"UOC Medicina Interna AO Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Malizia","sequence":"additional","affiliation":[{"name":"UOC Gastroenterologia AO Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Montineri","sequence":"additional","affiliation":[{"name":"UOC Malattie infettive AO Universitaria V. Emanuele di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Digiacomo","sequence":"additional","affiliation":[{"name":"UOC Medicina Interna Ospedale di Comiso ASP Ragusa  Ragusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-6121","authenticated-orcid":false,"given":"Anna","family":"Licata","sequence":"additional","affiliation":[{"name":"UOC Medicina Interna AOUP Paolo Giaccone  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Benanti","sequence":"additional","affiliation":[{"name":"UOC Malattie Infettive ARNAS Garibaldi\u2010Nesima  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Bertino","sequence":"additional","affiliation":[{"name":"UOC Medicina Interna AO Universitaria V. Emanuele di Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Enea","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit Department of Health Promotion Sciences Maternal and Infantile Care Internal Medicine and Medical Specialities PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit Department of Health Promotion Sciences Maternal and Infantile Care Internal Medicine and Medical Specialities PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Squadrito","sequence":"additional","affiliation":[{"name":"UOC Epatologia Clinica e Biomolecolare  Messina Italy"},{"name":"AOUP G. 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of Viral 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