{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:31:16Z","timestamp":1787164276101,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NMRPG8G6102"],"award-info":[{"award-number":["NMRPG8G6102"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107\u2010TDU\u2010B\u2010212\u2010114022"],"award-info":[{"award-number":["MOHW107\u2010TDU\u2010B\u2010212\u2010114022"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW108\u2010TDU\u2010B\u2010212\u2010124022"],"award-info":[{"award-number":["MOHW108\u2010TDU\u2010B\u2010212\u2010124022"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW109\u2010TDU\u2010B\u2010212\u2010134022"],"award-info":[{"award-number":["MOHW109\u2010TDU\u2010B\u2010212\u2010134022"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated the ability of hepatitis B core\u2010related antigen (HBcrAg) to predict hepatitis B virus (HBV) relapse in HBeAg\u2010negative patients after cessation of entecavir therapy. A total of 301 HBeAg\u2010negative patients without cirrhosis who had stopped entecavir therapy for at least 12\u00a0months were recruited. All patients fulfilled the stopping criteria proposed by the APASL 2012 guidelines. The five\u2010year cumulative rates of virological relapse, clinical relapse and HBsAg loss were 71.6%, 57.3% and 18.7%, respectively. Serum HBsAg at end of treatment (EOT) was an independent predictor of virological relapse, clinical relapse and HBsAg loss; an EOT HBsAg of 150\u00a0IU\/ml was the optimal cut\u2010off value. The 5\u2010year virological relapse rates for patients with &lt;150 and \u2265150\u00a0IU\/ml HBsAg at EOT were 43.3% and 82.2% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), clinical relapse rates were 32.3% and 66.3% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), and HBsAg loss rates were 46.1% and 5.2% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), respectively. A baseline HBcrAg of 4\u00a0IU\/ml was the optimal cut\u2010off value for predicting HBV relapse. Among patients with an EOT HBsAg &lt;150\u00a0IU\/ml, the five\u2010year virological relapse rates for patients with baseline HBcrAg levels \u22644 and &gt;4 log U\/ml were 27.9% and 59.1% (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.006) and the clinical relapse rates were 18% and 48.1% (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.014), respectively. EOT HBcrAg was not a significant predictor of virological\n                    <jats:styled-content>or<\/jats:styled-content>\n                    clinical relapse after cessation of entecavir. In conclusion, the combination of an EOT HBsAg of 150\u00a0IU\/ml and baseline HBcrAg of 4 log U\/ml can effectively predict the risk of HBV relapse after stopping entecavir therapy.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13528","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T11:05:45Z","timestamp":1619867145000},"page":"1141-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of hepatitis B virus core\u2010related antigen in predicting hepatitis B virus relapse after cessation of entecavir in hepatitis B e antigen\u2010negative patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Pao\u2010Yuan","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Houng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Nan","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health O.Global Hepatitis P. 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