{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:27:23Z","timestamp":1775154443804,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C4070136"],"award-info":[{"award-number":["2019R1A2C4070136"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cirrhosis has prognostic value. We investigated whether the combined use of ultrasonography (US) and transient elastography (TE) to diagnose cirrhosis is beneficial for the risk assessment of hepatocellular carcinoma (HCC) and liver\u2010related events in patients with chronic hepatitis B (CHB). A total of 9300 patients with CHB who underwent US and TE in two institutions between 2006 and 2018 were enrolled. TE value \u226513\u00a0kPa was set to indicate cirrhosis. Patients were divided into four groups: US(+)TE(+) (cirrhosis by US and TE), US(+)TE(\u2212) (cirrhosis by US, but not by TE), US(\u2212)TE(+) (cirrhosis by TE, but not by US) and US(\u2212)TE(\u2212) (non\u2010cirrhosis by US and TE).The patients were predominantly male (<jats:italic>n<\/jats:italic>\u00a0=\u00a05474, 58.9%) with a mean age of 47.5\u00a0years. The proportions of patients with cirrhosis diagnosed by US and TE were 17.2% (<jats:italic>n<\/jats:italic>\u00a0=\u00a01595) and 13.2% (<jats:italic>n<\/jats:italic>\u00a0=\u00a01225), respectively. The proportion of patients with discordant results in diagnosing cirrhosis by US and TE was 18.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a01740). During follow\u2010up (median: 60.0\u00a0months), HCC and liver\u2010related events developed in 481 (5.2%) and 759 (8.2%) patients, respectively. The cumulative incidence rates of HCC and liver\u2010related events were highest in the US(+)TE(+) group, intermediate\u2010high in the US(\u2212)TE(+) group, intermediate\u2010low in the US(+)TE(\u2212) group and lowest in the US(\u2212)TE(\u2212) group (overall <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Cirrhosis assessed using US and TE was a major predictor of HCC and liver\u2010related event development in patients with CHB. Cirrhosis assessed using TE seemed better in predicting HCC or liver\u2010related events than using US, when cirrhosis diagnosis was discordant by US and TE.<\/jats:p>","DOI":"10.1111\/jvh.13560","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T17:16:25Z","timestamp":1624986985000},"page":"1362-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk assessment of hepatocellular carcinoma and liver\u2010related events using ultrasonography and transient elastography in patients with chronic hepatitis B"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-1052","authenticated-orcid":false,"given":"Sung Hwan","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Internal Medicine Gangnam Severance Hospital Seoul 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