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We aimed to clarify the impact of viral eradication on hepatocarcinogenesis and mortality in patients with mild fibrosis.The subjects were 657 patients who achieved sustained virologic response (SVR) (Clearance group) and 586 patients who did not receive antiviral therapy or did not achieve SVR (No clearance group). We applied inverse probability weighting because the groups had different baseline characteristics. Multivariate proportional hazards models were used to analyse factors associated with hepatocarcinogenesis and mortality using a time\u2010dependent covariate. In addition, we compared the mortality rate of the Clearance group stratified by age to the mortality rate of the general population.Clearance of HCV RNA was significantly associated with hepatocarcinogenesis and all\u2010cause, liver\u2010related and non\u2013liver\u2010related mortality (adjusted hazard ratios [95% confidence interval], 0.2653 [0.1147\u20130.6136, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0019], 0.3416 [0.2157\u20130.5409, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001], 0.2474 [0.0802\u20130.8917, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0381] and 0.4118 [0.2449\u20130.6925, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0008], respectively). The Clearance group had significantly higher mortality than the general population matched by age, sex and follow\u2010up duration (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). However, there were no significant differences between patients who achieved SVR before age 50 and the general population matched by age, sex and follow\u2010up duration (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.1570). HCV eradication in patients with mild fibrosis reduces liver\u2010related and non\u2013liver\u2010related mortality. If HCV is eradicated before age 50, prognosis is likely be similar to that of the age\u2010matched and sex\u2010matched general population. 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