{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:54:44Z","timestamp":1767182084859,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have showed that combining peg\u2010interferon alpha (Peg\u2010IFN\u03b1) with nucleotide analogues has complementary effects in chronic hepatitis B (CHB), but the optimal regimen and potential mechanisms remain unclear. This was a prospective, longitudinal and multicentre clinical trial (NCT03013556). HBeAg\u2010positive CHB na\u00efve patients were randomly assigned to three groups: tenofovir disoproxil fumarate (TDF) monotherapy for 96\u00a0weeks, TDF alone for 48\u00a0weeks and sequentially Peg\u2010IFN\u03b1 added for 48\u00a0weeks, TDF de novo combination with Peg\u2010IFN\u03b1 for 48\u00a0weeks then TDF alone for 48\u00a0weeks. The primary endpoint was HBeAg seroconversion at week 96 and HBsAg loss as the secondary endpoint. Furthermore, the levels of 12 cytokines in serum were assessed at different time points. A total of 133 patients were included in the analysis. The rates of HBeAg seroconversion at 96\u00a0weeks were not significant different among the three groups (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.157). Interestingly, patients in the Peg\u2010IFN\u03b1 add\u2010on group showed markedly lower HBsAg level compared with the other two groups at week 96. In addition, only three patients in the Peg\u2010IFN\u03b1 add\u2010on group achieved HBsAg loss. For the following 24\u00a0weeks from week 96, no HBsAg reappearance in the three patients and no new patients with HBsAg loss were observed in the three groups. Serum cytokine analysis showed that the baseline level of interferon\u2010inducible protein\u201010 (IP\u201010) was strongly higher in HBeAg conversion patients and HBsAg loss patients. Compared with de novo combination and TDF alone, the addition of Peg\u2010IFN\u03b1 in TDF\u2010treated group might be an effective strategy for HBsAg loss in HBeAg\u2010positive CHB na\u00efve patients.<\/jats:p>","DOI":"10.1111\/jvh.13571","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T18:51:27Z","timestamp":1625597487000},"page":"1381-1391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peg\u2010interferon alpha add\u2010on Tenofovir disoproxil fumarate achieved more HBsAg loss in HBeAg\u2010positive chronic hepatitis B na\u00efve patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Research Laboratory of Clinical Virology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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