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This systematic review assessed reported data on the HCV care cascade in various countries and populations, with a focus on direct\u2010acting antiviral (DAA) treatment uptake. Bibliographic databases and conference presentations were searched for studies reporting the HCV care cascade (DAA treatment uptake was a requirement) among the overall population with HCV or sub\u2010populations at greater risk of HCV. Population\u2010based studies, with participants representative of a city, province\/state or country were eligible. Twenty eligible studies were included, reporting HCV care cascade in 28 populations\/sub\u2010populations from 11 countries. DAA treatment uptake at national levels was reported from Iceland (95%), Egypt (92%), Georgia (79%), Norway (18%) and Sweden (8%), and at sub\u2010national levels from the Netherlands (52%), Canada (50%), the United States (29%) and Denmark (5%). Among people with HIV\u2010HCV co\u2010infection, DAA treatment uptake was 62% in Canada, 44% in the Netherlands, 21% in Switzerland and 18% in the United States. Among people who inject drugs, DAA treatment uptake was 50% in Georgia, 40% in Canada, 37% in Australia and 13% in the United States. Data among people experiencing homelessness were only available from the United States (treatment uptake: 12%\u201314%). We found no eligible study reporting HCV care cascade data in prisons. Relatively few countries reported HCV care cascade at the national level. DAA treatment uptake was widely varied across populations\/sub\u2010populations, with higher rates reported in recent years.<\/jats:p>","DOI":"10.1111\/jvh.13574","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T18:03:20Z","timestamp":1627322600000},"page":"1340-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Global cascade of care for chronic hepatitis C virus infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-8323","authenticated-orcid":false,"given":"Mohammad T.","family":"Yousafzai","sequence":"first","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-3845","authenticated-orcid":false,"given":"Sahar","family":"Bajis","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1358","authenticated-orcid":false,"given":"Maryam","family":"Alavi","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-2017","authenticated-orcid":false,"given":"Jason","family":"Grebely","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-2622","authenticated-orcid":false,"given":"Gregory J.","family":"Dore","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-2028","authenticated-orcid":false,"given":"Behzad","family":"Hajarizadeh","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_11_3_1","volume-title":"Global Hepatitis Report 2017","author":"World Health Organization","year":"2017"},{"key":"e_1_2_11_4_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021: Towards Ending Viral Hepatitis","author":"World Health Organization","year":"2016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30270-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000081"},{"key":"e_1_2_11_7_1","unstructured":"US Department of Health and Human Services.HIV care continuum 2021.https:\/\/www.hiv.gov\/federal\u2010response\/policies\u2010issues\/hiv\u2010aids\u2010care\u2010continuum(accessed May 06 2021)."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14324"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13013"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"1","article-title":"Estimating the year each state in the United States will achieve the World Health Organization's elimination targets for hepatitis C","volume":"38","author":"Sulkowski M","year":"2020","journal-title":"Adv Ther"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232186"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.11.014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1912628"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","unstructured":"OlafssonS FridriksdottirRH TyrfingssonT et al.Iceland may already have reached the WHO 2030 targets for diagnosis and treatment of hepatitis C virus infection. 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