{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:35:08Z","timestamp":1780558508970,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term effects on cirrhosis and portal hypertension of direct antiviral agent (DAA)\u2010based eradication of hepatitis C virus (HCV) are still under debate. We analysed dynamics of liver and spleen elastography to assess potential regression of cirrhosis and portal hypertension 3\u00a0years post\u2010treatment. Fifty\u2010four patients with HCV\u2010associated cirrhosis and DAA\u2010induced SVR were included. Liver and spleen stiffness were measured at baseline (BL), end of treatment (EOT), 24\u00a0weeks after EOT (FU24) and 1, 2 and 3 (FU144) years post\u2010treatment by transient liver elastography (L\u2010TE) and point shear wave elastography (pSWE) using acoustic radiation force impulse (ARFI) of the liver (L\u2010ARFI) and spleen (S\u2010ARFI). Biochemical, virological and clinical data were also obtained. Liver stiffness assessed by L\u2010TE decreased between BL [median (range), 32.5(9.1\u201375) kPa] and EOT [21.3(6.7\u201373.5) kPa; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.0001] and EOT and FU144 [16(4.1\u201375) kPa; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.006]. L\u2010ARFI values improved between EOT [2.5(1.2\u20134.1) m\/s] and FU144 [1.7(0.9\u20134.1) m\/s; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.001], while spleen stiffness remained unchanged. Overall, L\u2010TE improved in 38 of 54 (70.4%) patients at EOT and 29 of 38 (76.3%) declined further until FU144, whereas L\u2010ARFI values decreased in 30\/54 (55.6%) patients at EOT and continued to decrease in 28\/30 (93.3%) patients at FU144. Low bilirubin and high albumin levels at BL were associated with improved L\u2010ARFI values (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.048) at EOT or regression of cirrhosis (&lt;12.5\u00a0kPa) by L\u2010TE at FU144 (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.005), respectively. Liver stiffness, but not spleen stiffness, continued to decline in a considerable proportion of patients with advanced liver disease after HCV eradication.<\/jats:p>","DOI":"10.1111\/jvh.13587","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T07:12:06Z","timestamp":1627974726000},"page":"1604-1613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Non\u2010invasive assessment of fibrosis regression and portal hypertension in patients with advanced chronic hepatitis C virus (HCV)\u2010associated liver disease and sustained virologic response (SVR): 3 years follow\u2010up of a prospective longitudinal study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-5218","authenticated-orcid":false,"given":"Viola","family":"Knop","sequence":"first","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"},{"name":"St. Elisabeth\u2010Krankenhaus Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Vermehren","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Troetschler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"},{"name":"Ketteler Krankenhaus Offenbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biostatistik und mathematische Modellierung Goethe\u2010Universit\u00e4t Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Vermehren","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireen","family":"Friedrich\u2010Rust","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"},{"name":"St\u2010Josefs\u2010Hospital Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u2010Walter","family":"Welker","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887114666190306154650"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.12.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512614"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.03.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12331"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.050"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12706"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12578"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.86"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12240"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz161"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12628"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2013.03.023"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13256"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.262.dyn"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19418"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-019-00597-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000400"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.035"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26239"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001458"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_8_30_1","first-page":"50","volume-title":"Surgery and Portal Hypertension","author":"Child CG","year":"1964"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312444"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.034"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2003.07.001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02100.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23425"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01537.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(01)00499-9"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1356230"},{"key":"e_1_2_8_42_1","first-page":"587","article-title":"Noninvasive assessment of fibrosis regression in hepatitis C virus sustained virologic responders","volume":"10","author":"Trivedi HD","year":"2017","journal-title":"Gastroenterol&Hepatol"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1228"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31462"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13844"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.013"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30885"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.03.029"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200213"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.12.001"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28610"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17715198"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v10.i10.731"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21665"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.016"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14041"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190826150344"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:28:36Z","timestamp":1693301316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jvh.13587"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13587","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}