{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:37:14Z","timestamp":1792103834810,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The influence of hepatic steatosis on the natural history of chronic hepatitis B (CHB) virus is unclear. Therefore, we investigated whether concurrent steatosis in patients with CHB influences the probability of hepatitis B surface antigen (HBsAg) loss, fibrosis progression and hepatocellular carcinoma (HCC) development. This study enrolled treatment\u2010na\u00efve patients with virologically (HBV DNA &lt;2,000\u00a0IU\/ml) and biochemically (alanine aminotransferase level &lt;40\u00a0IU\/L) quiescent CHB who underwent transient elastography between January 2004 and December 2015 and completed 3\u00a0years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the study population (<jats:italic>n<\/jats:italic>\u00a0=\u00a0720) was 52.0\u00a0years, and there were more men than women (<jats:italic>n<\/jats:italic>\u00a0=\u00a0419, 58.2%). The mean HBV DNA level was 321.6\u00a0IU\/ml. During the 3\u2010year period, 74 (10.3%) patients achieved HBsAg seroclearance. Lower HBV DNA levels (hazard ratio\u00a0=\u00a00.995, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) were independently associated with HBsAg seroclearance, while hepatic steatosis was not (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). Fibrosis progressed in 89 (12.4%) patients. Male gender (odds ratio [OR]\u00a0=\u00a01.720) and higher body mass index (OR\u00a0=\u00a01.083) were independently associated with an increased probability of fibrosis progression (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), while higher total cholesterol levels (OR\u00a0=\u00a00.991) and higher liver stiffness values (OR\u00a0=\u00a00.862) were independently associated with a decreased probability of fibrosis progression (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). HCC developed in 46 (6.4%) patients. Male gender (OR\u00a0=\u00a03.917) and higher AST levels (OR\u00a0=\u00a01.036) were independently associated with an increased probability of HCC development (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Hepatic steatosis was not associated with the probability of HBsAg seroclearance, fibrosis progression or HCC development in patients quiescent CHB in our study. Further studies with longer follow\u2010up periods are required to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jvh.13594","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T09:24:23Z","timestamp":1628760263000},"page":"1545-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["No influence of hepatic steatosis on the 3\u2010year outcomes of patients with quiescent chronic hepatitis B"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9142-7111","authenticated-orcid":false,"given":"Jin Won","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-0967","authenticated-orcid":false,"given":"Jae 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