{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:33:38Z","timestamp":1774488818313,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z181100001718035"],"award-info":[{"award-number":["Z181100001718035"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803299"],"award-info":[{"award-number":["81803299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The long\u2010term benefits of interferon\u2010\u03b1 (IFN\u2010\u03b1) treatment in children with chronic hepatitis B (CHB) remain unclear. We conducted a retrospective and real\u2010world study to evaluate the safety and long\u2010term clearance rates of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) in CHB children who received IFN\u2010\u03b1 monotherapy for 72\u00a0weeks and were with 13\u2010year follow\u2010up visit. Participants treated with IFN\u2010\u03b1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0316) were more likely to become HBeAg negatve (39.87% vs. 27.37%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and HBsAg negative (11.08% vs. 3.16%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) by the end of the treatment period than untreated participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a095). Treated participants also had higher cumulative rates of HBeAg loss (74.13% vs. 59.27%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and HBsAg loss (46.95 vs. 33.11%; <jats:italic>p<\/jats:italic>\u00a0&lt; 0.05) than untreated participants in parallel by the end of 13\u2010year follow\u2010up. In particular, the cumulative rate of HBsAg loss was higher in treated children aged 1\u20137\u00a0years than in those aged 8\u201317\u00a0years (71.40% vs. 39.0%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.01). Children who were HBeAg\u2010negative at the end of IFN\u2010\u03b1 treatment or who had serum alanine aminotransferase levels of\u00a0\u226580\u00a0IU\/L at baseline were likely to have higher cumulative HBsAg loss rates. Accordingly, HBeAg loss at 72\u00a0weeks was positively associated with the cumulative HBsAg loss rate in untreated children. There were no serious adverse events of IFN\u2010\u03b1 therapy for the treated patients throughout the study period. Overall, IFN\u2010\u03b1 therapy was effective in obtaining higher long\u2010term cumulative rates of HBeAg and HBsAg loss in children with HBeAg\u2010positive immune\u2010active CHB, especially among those aged 1\u20137\u00a0years.<\/jats:p>","DOI":"10.1111\/jvh.13598","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T02:11:14Z","timestamp":1630030274000},"page":"1554-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term benefits of interferon\u2010\u03b1 therapy in children with HBeAg\u2010positive immune\u2010active chronic hepatitis B"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-5771","authenticated-orcid":false,"given":"Limin","family":"Wang","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA China"},{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Live disease Fifth Medical Center of Chinese Fifth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA China"},{"name":"Department of Infectious Disease Fifth Medical Center of Chinese PLA General Hospital Beijing 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