{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:58:37Z","timestamp":1784033917295,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is unclear whether tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF) is more effective for preventing hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB). In this study, we compared the effectiveness of these two antiviral agents for preventing HCC. We included treatment\u2010na\u00efve CHB patients undergoing antiviral therapy with TDF only (TDF group) or a TAF\u2010based regimen (TAF group) at three academic teaching hospitals from 2012 to 2019. The TAF group included patients receiving TAF as first\u2010line treatment and patients switching from TDF to TAF. Patients with decompensated cirrhosis or HCC at enrollment were excluded. Cumulative probabilities of HCC were assessed using Kaplan\u2010Meier methodology. In total, 2,117 patients were included: 1,832 in the TDF group and 285 in the TAF group. The annual HCC incidence was not significantly different between TDF and TAF groups: 1.66 vs. 1.19 per 100 person\u2010years [PY], respectively (multivariate analysis: adjusted hazard ratio [HR] 0.774 [reference: TDF group]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.438). Male, liver cirrhosis, hepatitis B e antigen negativity, Fibrosis\u20104 index&gt;3.25 and low albumin were independently associated with a higher risk of HCC. Propensity score\u2010matched and inverse probability of treatment weighting analyses yielded similar results: 1.56 vs. 1.19 per 100 PY, respectively (HR 1.175; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.708) and 1.66 vs. 1.29 per 100 PY, respectively (HR 0.888; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.446). The risk of HCC development was not significantly different between TDF and TAF groups of CHB patients. Further studies with a larger sample size and longer follow\u2010up are required to validate our results.<\/jats:p>","DOI":"10.1111\/jvh.13601","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T08:58:34Z","timestamp":1629968314000},"page":"1570-1578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of tenofovir alafenamide vs. tenofovir disoproxil fumarate on hepatocellular carcinoma risk in chronic hepatitis B"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-3560","authenticated-orcid":false,"given":"Hye Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Youn","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung Ang University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-8366","authenticated-orcid":false,"given":"Hyein","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-0967","authenticated-orcid":false,"given":"Jae Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-2224","authenticated-orcid":false,"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei University Health System Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital, Yonsei 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