{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:09:19Z","timestamp":1782472159022,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW106\u2010CDC\u2010C\u2010114\u2010123111"],"award-info":[{"award-number":["MOHW106\u2010CDC\u2010C\u2010114\u2010123111"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tenofovir disoproxil fumarate (TDF) is the preferred treatment to prevent mother\u2010to\u2010infant transmission in highly viremic HBV\u2010infected women. Data on hepatitis B surface antigen (HBsAg) levels in pregnant women are lacking. We aimed to investigate prepartum and postpartum HBsAg kinetics and its correlation with HBV DNA in pregnant women. HBV\u2010infected mothers with HBV DNA \u22657.5\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/ml were tested for HBsAg and HBV DNA from baseline to 6\u00a0months postpartum. Of the 186 pregnant women with comparable baseline HBsAg and HBV DNA, 101 received TDF from the third trimester until 1\u00a0month postpartum. At delivery, TDF group had mildly lower HBsAg (4.32\u00a0\u00b1\u00a00.47 vs. 4.54\u00a0\u00b1\u00a00.35\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0004) and markedly lower HBV DNA (4.26\u00a0\u00b1\u00a00.97 vs. 8.11\u00a0\u00b1\u00a00.70\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) than the control group. In the TDF group, mean reduction of HBsAg and HBV DNA from baseline to delivery were 0.22\u00a0\u00b1\u00a00.38 and\u20093.96\u00a0\u00b1\u00a00.93\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/ml. HBsAg reduction had a positive correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.309; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0017) with HBV DNA reduction, and was predictive of HBV DNA reduction \u22653\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/ml (area under the receiver operating characteristic curve, 0.67; 95% confidence interval, 0.50\u20130.82). At 6\u00a0months postpartum, TDF and control group had comparable HBsAg and HBV DNA. In conclusion, HBsAg decreased slightly at delivery in pregnant women receiving TDF. For monitoring the effect of antiviral therapy during pregnancy, HBV DNA is a better marker than HBsAg. Our data provided valuable information regarding monitoring HBV\u2010infected pregnant women using antiviral therapy.<\/jats:p>","DOI":"10.1111\/jvh.13628","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T16:45:29Z","timestamp":1635785129000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Kinetics of hepatitis B surface antigen in pregnant women with and without tenofovir disoproxil fumarate"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-5686","authenticated-orcid":false,"given":"Huai\u2010Lung","family":"Chang","sequence":"first","affiliation":[{"name":"School of Medicine National Taiwan University College of Medicine Taipei 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