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We aim to estimate the incidence of hepatitis D\u2010associated hospitalizations in the United States and describe the clinical, demographic and geographic characteristics of those hospitalizations. We utilized hospitalization data from the 2010\u20132018 National Inpatient Sample from the Healthcare Cost and Utilization Project. Hepatitis D and hepatitis B only (HBV only) hospitalizations were identified by International Classification of Diseases, Ninth Revision (ICD\u20109) and International Classification of Diseases, Tenth Revision (ICD\u201010) codes. We identified 3825 hepatitis D\u2010associated hospitalizations. The hospitalization rate of hepatitis D was between 6.9 and 20.7 per 10,000,000 but did not change significantly over time. Compared to HBV only, the hepatitis D cohort had a greater proportion of males, Hispanics, hospitalizations in the Northeast region. The hepatitis D\u2010associated hospitalizations also had significantly greater frequencies of liver failure, non\u2010alcoholic cirrhosis, portal hypertension, ascites and thrombocytopenia. While mortality in hepatitis D was similar to that of HBV only, age &gt;65 years (odds ratio [OR]\u00a0=\u00a03.79; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.020) and having a diagnosis of alcoholic cirrhosis (OR\u00a0=\u00a03.37; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.044) increased the odds of mortality within the hepatitis D cohort. Although the hepatitis D\u2010associated hospitalizations were relatively uncommon, they were associated with severe complications.<\/jats:p>","DOI":"10.1111\/jvh.13645","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T08:41:08Z","timestamp":1643100068000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatitis D\u2010associated hospitalizations in the United States: 2010\u20132018"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-453X","authenticated-orcid":false,"given":"Paul","family":"Wasuwanich","sequence":"first","affiliation":[{"name":"University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine W.","family":"Striley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health and Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleem","family":"Kamili","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Viral Hepatitis, STD and TB Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyasu H.","family":"Teshale","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Viral Hepatitis, STD and TB Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Seaberg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-5459","authenticated-orcid":false,"given":"Wikrom","family":"Karnsakul","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(18)30056\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010316601"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61931\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010017\u20100845\u2010y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8644"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.03.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.035"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.12.028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101323628"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2019.0048"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.09.058"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102893.2010.01353.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24927"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001400\u20101"},{"key":"e_1_2_10_17_1","unstructured":"HCUP Nationwide Inpatient Sample (NIS). 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