{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:22:05Z","timestamp":1774084925516,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alfosbuvir is a novel potent HCV NS5B polymerase inhibitor in development for the treatment of chronic HCV infection. Our previous studies indicated that alfosbuvir monotherapy was well\u2010tolerated and druggable in healthy subjects and HCV\u2010infected patients. Here, we evaluate the efficacy and safety of alfosbuvir in combination with daclatasvir in Chinese patients with HCV genotype 1, 2, 3 or 6. In this open\u2010label study, patients with chronic HCV infection were randomly assigned with a 1:1:1 ratio to receive 12\u00a0weeks of daclatasvir 60\u00a0mg plus alfosbuvir at a dose of 400, 600 or 800\u00a0mg (Cohort A, B or C) daily. Randomization was stratified by HCV genotype and the presence or absence of cirrhosis at screening. The primary endpoint was a sustained virologic response 12\u00a0weeks after the end of treatment (SVR12). A total of 124 patients were enrolled in the study, all of whom were available for post\u2010treatment week 12 assessments. SVR12 was achieved in 92.7% (38\/41), 95.2% (40\/42) and 100% (41\/41) of patients in Cohort A, B and C respectively. The most common adverse events were hepatic steatosis, upper respiratory tract infection, hypercholesterolaemia, hypertriglyceridaemia, blood bilirubin increased, and total bile acids increased. There were no discontinuations due to adverse events, and no treatment\u2010related serious adverse events were reported. Once\u2010daily oral administration of alfosbuvir plus daclatasvir were highly effective and safe in Chinese patients infected with HCV genotype 1, 2, 3 or 6, suggesting this regimen could be a promising drug candidate for HCV treatment irrespective of genotype.<\/jats:p><jats:p>(ClinicalTrials.gov number, NCT04070235).<\/jats:p>","DOI":"10.1111\/jvh.13650","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:24:25Z","timestamp":1643196265000},"page":"455-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of alfosbuvir plus daclatasvir in Chinese patients with hepatitis C virus genotypes 1, 2, 3, and 6 infection: An open\u2010label, phase 2 study"],"prefix":"10.1111","volume":"29","author":[{"given":"Rui","family":"Hua","sequence":"first","affiliation":[{"name":"The First Hospital of Jilin University  Changchun 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